Efficacy Analysis of the Combination Therapy of Glibenclamide and Metformin in the Treatment of Elderly Patients with Diabetes Mellitus

Tao-Tao Yao

doi:https://doi.org/10.37155/3060-8708-0203-7

Home > Current

Efficacy Analysis of the Combination Therapy of Glibenclamide and Metformin in the Treatment of Elderly Patients with Diabetes Mellitus

Tao-Tao Yao （ Qingyuan Town Health Center of Weiyuan County, Dingxi, Gansu, 748200, China ）

https://doi.org/10.37155/3060-8708-0203-7

Abstract

Objective: To investigate the clinical efficacy of the compound preparation of glibenclamide and metformin in the treatment of elderly diabetic patients. Methods: A total of 120 elderly patients (aged ≥65 years) with type 2 diabetes mellitus who were treated at our hospital from January 2022 to June 2025 were selected. Patients were randomly divided into an observation group and a control group, with 60 cases in each group. The observation group received treatment with the glibenclamide-metformin compound preparation, while the control group was treated with glibenclamide alone. The treatment duration was 12 weeks. Blood glucose control, improvement of islet function, and incidence of adverse reactions before and after treatment were compared between the two groups. Results: The observation group showed significantly better blood glucose control and greater improvement in islet function than the control group, with a lower incidence of adverse reactions (P

Keywords

Glibenclamide; Metformin; Compound preparation; Elderly diabetes; Clinical efficacy

Full Text

PDF

References

[1] Zeng Qiumei, Luo Cheng, Hu Yonghong. Effect of Glibenclamide and Metformin on Gestational Diabetes Mellitus and Pregnancy Outcomes. Journal of Chinese Family Planning, 2022, 30(12): 2749–2753.
[2] Zhang Chenxin, Yang Shan. Effect of Metformin Hydrochloride Combined with Glibenclamide on Serum VEGF, APN, and Hcy in Patients with Gestational Diabetes Mellitus. Journal of Chinese Family Planning, 2021, 29(2): 288–291.
[3] Gao Kun, Wang Bing. Clinical Observation of Glibenclamide Combined with Metformin in the Treatment of Gestational Diabetes Mellitus. Chinese Pharmaceuticals, 2020, 29(2): 78–80.
[4] Lu Xiujun. Effect and Safety of Glibenclamide Combined with Metformin in the Treatment of Gestational Diabetes Mellitus. Diabetes New World, 2021, 24(7): 107–110.
[5] Yin Aili. Effect of Combined Use of Metformin Hydrochloride and Glibenclamide on Serum VEGF, APN, and Hcy in Patients with Gestational Diabetes Mellitus. Studies on Women’s Health, 2023(6): 111–113.
[6] Liu Jiarui, Ye Shandong, Bi Shuangjie, et al. Effect of Metformin on the Expression of Macrophage Migration Inhibitory Factor and Its Receptor CD74 in the Renal Tissue of Type 2 Diabetic Rats. Journal of Anhui Medical University, 2021, 56(1): 6–10.

Publishing time:2025-06-30
This work is licensed under a Creative Commons Attribution 4.0 International License