Vol 2 No 6 (2025)
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Sex differences in lacrimal gland lesions in a streptozotocin-induced diabetic mouse model
Tingting Xu, Lingling Yang, Jun Cheng
Objective: To investigate gender-based differences in the progression of lacrimal gland lesions in diabetic mice. Methods: Sixty-four C57BL/6 mice of each sex (64 males, 64 females) were used. Mice of each sex were divided into a diabetic group and a control group (n = 32 per group). The diabetic group received intraperitoneal streptozotocin for five consecutive days; controls received citrate buffer. At 1, 2, 3, and 8 months post-injection, body weight, blood glucose, corneal sensitivity, and tear secretion were measured. Lacrimal glands were examined histologically and for inflammatory factor expression. Results: Diabetic mice showed significantly lower body weight and tear secretion, and higher blood glucose than controls at all time points. Male diabetic mice exhibited greater body weight loss than females throughout, and greater tear reduction at 1 month. Corneal sensitivity decreased significantly in diabetics from 2 months onward, with no sex difference. Lacrimal gland weight was significantly reduced in diabetics at 3 and 8 months, with greater reduction in males. Inflammatory cell infiltration appeared at 3 months and intensified by 8 months in both sexes. At 8 months, TNF-α and IL-1β expression was significantly elevated in diabetic males but not females. Conclusion: Both male and female diabetic mice developed dry eye-related pathologies, but males showed more severe lacrimal gland lesions, suggesting they may be a more suitable model for studying diabetic lacrimal gland complications.
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Research on the Development of Application and Protection in Radiation Medicine
Ting Wang
With the rapid advancement of medical technology, radiation medicine has assumed an increasingly important role in clinical diagnosis, treatment, and scientific research. Its core applications encompass radiation sterilization, tumor therapy, and medical imaging technologies, providing critical support for disease diagnosis and treatment. However, the potential hazards of ionizing radiation cannot be overlooked, making protection a central aspect in ensuring the safety of healthcare professionals and patients. Currently, emerging technologies such as artificial intelligence-assisted diagnosis, robot-assisted surgery, and the application of new protective materials are driving radiation medicine toward safer and more precise directions.
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Application Research on the Intervention of Chronic Disease Management Platform Combined with Traditional Chinese Medicine for Elderly Type 2 Diabetes Mellitus
Chen Zheng, Zhun Zhong, Hong-Xia Ji
Objective: To explore the effects of integrating a chronic disease management platform with traditional Chinese medicine interventions on glycemic control, self-management ability, and psychological health status in elderly patients with type 2 diabetes. Methods: A total of 180 elderly patients with type 2 diabetes who visited the endocrinology outpatient clinic of Sheyang County Hospital of Traditional Chinese Medicine from September 2024 to September 2025 were selected. Patients were randomly divided into a control group and an experimental group using computer-generated random numbers. The control group received routine outpatient care and traditional Chinese medicine treatment, while the experimental group received additional information support interventions via the chronic disease management platform on top of the control group's treatment. Glycemic control indicators, self-management ability, and psychological health status were compared between the two groups before and after the intervention. Results: The experimental group showed superior outcomes in glycemic control, self-management ability improvement, and alleviation of anxiety and depression compared to the control group (P<0.05). Conclusion: The integration of a chronic disease management platform with traditional Chinese medicine interventions can effectively improve glycemic control, enhance self-management ability, and ameliorate psychological health status in elderly patients with type 2 diabetes.
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Biofilm Formation During Reprocessing of Reusable Medical Devices and Strategies for Its Elimination
Yi Ding, Min Yang, Xin-Hui Ma
Device-Associated Infections (DAIs) represent a significant global challenge to healthcare safety, and the formation of biofilms is widely recognized as one of their core pathogenic mechanisms. Throughout the entire process of cleaning, disinfection, and sterilization of medical devices (i.e., reprocessing), improper operation or procedural deficiencies may allow residual organic matter and microorganisms to adhere to device surfaces and rapidly develop into highly resistant biofilms. These biofilms act as persistent “hidden contamination sources,” posing serious threats to patient safety. This paper systematically elaborates on the fundamental concepts and formation mechanisms of biofilms, as well as their dynamic evolution during each stage of medical device reprocessing (pre-treatment, cleaning, disinfection, sterilization, and drying/storage). It further analyzes key risk factors contributing to biofilm formation within current reprocessing workflows and comprehensively reviews recent advances and practical applications of physical, chemical, and emerging biofilm removal strategies. The aim of this study is to provide theoretical support and practical guidance for optimizing medical device reprocessing procedures, enhancing infection control, and safeguarding patient safety.
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Effect of Optimized Sleep Nursing in Critical Patients with Respiratory Medicine
Shuang Wu, Yu Wu, Zhi-Wen Huang
Objective: To observe the effect of optimized sleep nursing in severe patients in respiratory medicine department, and to explore a scientific nursing model to improve their sleep quality and promote recovery. Methods: A total of 86 critically ill patients admitted to the ICU of the Respiratory Department of our hospital were selected and divided into the control group and the observation group according to the nursing methods, with 43 cases in each group. The control group received routine sleep nursing, and the observation group received optimized sleep nursing. The sleep quality score, respiratory function index, complication rate and rehabilitation process before and after nursing were compared between the two groups. Results: After nursing, the sleep quality score of the observation group was lower, the respiratory function index was better, the complication rate (4.7%) was lower than that of the control group (18.6%), and the hospitalization time was shorter, and the difference was significant (P < 0.05). Conclusion: Optimized sleep nursing can improve patients' sleep, optimize respiratory function, reduce the risk of complications, and accelerate recovery, which is worthy of promotion.
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Application of Failure Mode and Effects Analysis in the Construction of Outpatient and Emergency Intravenous Infusion Procedures
Jing Zhao, Xue Han, Yu‑Juan Han, Jing‑Yi Guo, Yuan‑Yuan Liang
Objective: To address high-frequency failure modes such as medication incompatibility errors in the outpatient and emergency intravenous infusion process, an FMEA-based standardized process system was developed for proactive prevention and control. Methods: 400 patients were randomly divided into two groups. The observation group implemented a 12-step FMEA-driven process with closed-loop mechanisms, while the control group followed traditional procedures. Results: The observation group demonstrated significant reductions in failure frequency and risk priority numbers, with the relative risk of error incidence decreasing to 0.10–0.27. Procedure time was shortened by 17.6%, and high-risk step identification rates achieved high levels. Conclusion: This process effectively reduces medical risks, enables a paradigm shift in preventive strategies, and holds clinical promotion value.
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