The Effect of Balanced Analgesia with Sufentanil and Flurbiprofen Axetil in Patients with Cervical Cancer after Open Surgery

Tianxin Dong （ Affiliated Hospital of Chengde Medical University, Chengde 067000, Hebei Province, China ）

Abstract

Objective: To study the effect of balanced analgesia with sufentanil and flurbiprefen axetil in patients with cervical cancer after open surgery. Methods: 92 patients with cervical cancer treated in our hospital from October 2018 to December 2020 were selected. All patients were treated with open surgery for cervical cancer. According to the odd even grouping method, the patients were divided into observation group and control group, with 46 cases in each group. Sufentanil was used for postoperative analgesia in the control group, and sufentanil combined with flurbiprofen axetil was used for postoperative analgesia in the observation group. Serum prostaglandin E2 (PGE2), β Endorphins（β- EP), cortisol (COR), 5-hydroxytryptamine (5-HT), VAS score at different time points after operation and the number of presses of patient-controlled intravenous analgesia pump (PCIA) were compared. Results: Before operation, serum PGE2, β- Comparison of EP, Cor and 5-HT levels were compareed, P > 0.05; 24 hours after operation, the above indexes in the observation group were significantly lower than those in the control group (P < 0.05); The VAS scores of the observation group at different time points were lower than those of the control group (P < 0.05); The incidence of adverse reactions in the observation group was 6.52%, lower than 23.91% in the control group (P < 0.05). Conclusion: In the postoperative analgesia of patients with cervical cancer after open surgery, the application of sufentanil combined with flurbiprofen axetil balanced analgesia can not only reduce the secretion of related factors, but also improve the analgesic effect with less adverse reactions, which is worthy of clinical reference.

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