Correlation between Hp Infection with Clinicopathological Features, Tumor Markers, Oncogene Expression in Patients with Gastric Cancer
Jonathan Yeoh （ Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore 119228, Singapore ）https://doi.org/10.37155/2717-5278-2021-03-02-5
Objective: To study the correlation between Helicobacter pylori (Hp) infection with clinicopathological features, tumor markers, oncogene expression in patients with gastric cancer. Methods: 180 gastric cancer patients who underwent surgical resection in our hospital from February 2019 to March 2021 were selected. The clinicopathological characteristics of the patients were collected. The content of tumor markers was measured after serum collection. The HP infection and oncogene expression were measured after the collection of gastric cancer lesions and adjacent lesions. Results: The HP infection rate in 180 cases of gastric cancer was 56.67%; the HP infection rate in TNM stage III and TNM stage II was significantly higher than that in TNM stage I and the HP infection rate in TNM stage III was significantly higher than that in TNM stage II; the HP infection rate in poorly differentiated gastric cancer was significantly higher than that in moderately differentiated gastric cancer; the HP infection rate in gastric cancer tissues with depth of T3+T4 was significantly higher than that of T1+T2. The levels of serum CEA, CA19-9 and VEGF in patients with HP-positive gastric cancer tissues were significantly higher than those in patients with HP-negative gastric cancer tissues, the level of PGR was significantly lower than those in patients with HP-negative gastric cancer tissues; the mRNA expression of c-myc, c-Met and Bmi-1 in HP-positive gastric cancer tissues were significantly higher than those in HP-negative gastric cancer tissues; the mRNA expression of GKN1 and p16 were significantly lower than those in HP-negative gastric cancer tissues. Conclusion: Hp infection in patients with gastric cancer correlates with the changes of clinicopathological features, the increase of tumor markers and abnormal expression of oncogene.
KeywordsGastric cancer; Helicobacter pylori; Tumor marker; Oncogene
Jonaitis L, Pellicano R, Kupcinskas L. Helicobacter pylori and nonmalignant upper gastrointestinal diseases[J]. Helicobacter, 2018, 23(Suppl 1): e12522.
Xiaonan Li, Lei Zhang. Advances on the relationship between gastric cancer related genes and infection of Helicopter pylori[J]. Medical Research and Education, 2017, 34(3): 48-55.
Guixue Wei. Study on the correlation between Helicobacter pylori infection and gastric ulcer[J].Medical Laboratory Science and Clinics, 2017, 28(8): 50-51.
Jin Guo, Shengyi Wei. Correlation between Gastric Cancer and Helicobacter Pylori Infection, Duodenal Ulcer and Family History[J]. The Practical Journal of Cancer, 2017, 32(12): 2012-2013.
Díaz P, Valenzuela Valderrama M, Bravo J, et al. Helicobacter pylori and Gastric Cancer: Adaptive Cellular Mechanisms Involved in Disease Progression[J]. Front Microbiol, 2018, 22(9): 5.
Butcher LD, den Hartog G, Ernst PB, et al. Oxidative Stress Resulting From Helicobacter pylori Infection Contributes to GastricCarcinogenesis[J]. Cell Mol Gastroenterol Hepatol, 2017, 3(3):316-322.
Feige MH, Vieth M, Sokolova O, et al. Helicobacter pylori induces direct activation of the lymphotoxin beta receptor and non-canonical nuclear factor-kappa B signaling[J]. Biochim Biophys Acta, 2018, 1865(4):545-550.
Nguyen TT, Kim SJ, Park JM, et al. Repressed TGF-β signaling through CagA-Smad3 interaction as pathogenic mechanisms of Helicobacter pylori-associated gastritis[J]. J Clin Biochem Nutr, 2015, 57(2):113-120.
Xu Li. Value analysis of combined detection of CA724, CEA, CA242 and CA199 tumor markers in gastric cancer[J]. The Journal of Medical Theory and Practice, 2018, 31(4): 580-581.
Hanqing Chen, Chuxia Zhou. Changes of gastrin 17, pepsinogen, tumor markers and inflammatory factors in elderly patients with early gastric cancer[J]. Chinese Journal of Gerontology, 2018, 38(8): 1846-1847.
Wang L, Chang Y, Xu J, et al. Predictive Significance of Serum Level of Vascular Endothelial Growth Factor in Gastric CancerPatients[J]. Biomed Res Int, 2016, 2016: 8103019.
Taniguchi K, Iwatsuki A, Sugito N,et al. Oncogene RNA helicase DDX6 promotes the process of c-Myc expression in gastric cancer cells[J]. Mol Carcinog, 2018, 57(5):579-589.
Anestis A, Zoi I, Karamouzis MV. Current advances of targeting HGF/c-Met pathway in gastric cancer[J]. Ann Transl Med, 2018, 6(12):247.
Wang JL, Wu JH, Hong C, et al. Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16Ink4A/p14ARF gene expressions: An in vivo and in vitro study[J]. Pathol Res Pract, 2017, 213(12):1542-1551.
Pengjuan Sun, Zhifeng Li, Fang Liu, etc. Expression and significance of tumor suppressor genes GKN1 and P16 in gastric cancer[J]. Chinese Journal of Clinical and Experimental Pathology, 2016, 32(4): 437-439.
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