Observation of the Clinical Efficacy of Metformin and Pioglitazone in the Treatment of Type 2 Diabetes Mellitus Complicated with Coronary Heart Disease
Elias Abula （ Department of Endocrinology, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi Province, China ）
Shan Gao （ Department of Endocrinology, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi Province, China ）
https://doi.org/10.37155/2717-5278-0601-1Abstract
Objective: To analyze the application effects of metformin and pioglitazone in the treatment of type 2 diabetes mellitus (T2DM) complicated with coronary heart disease (CHD). Methods: A total of 82 patients with T2DM and CHD from November 2022 to November 2023 were selected for the study. Using a random number table, they were evenly divided into a control group (41 cases treated with pioglitazone) and an observation group (41 cases treated with a combination of metformin and pioglitazone). The clinical efficacy of the two groups was compared. Results: The incidence of adverse reactions in both groups was basically the same (P＞0.05); the observation group showed significantly lower rates of complications, fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG), glycated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol (TC), triglycerides (TG), and Gensini score than the control group (P＜0.05). Conclusion: Compared with monotherapy, the combined use of pioglitazone and metformin can enhance the clinical efficacy in treating T2DM complicated with CHD, regulate lipid indicators, and has potential for promotion.
Keywords
Metformin; Pioglitazone; Type 2 diabetes mellitus; Coronary heart diseaseFull Text
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Copyright © 2024 Elias Abula, Shan Gao
Publishing time:2024-02-27
This work is licensed under a Creative Commons Attribution 4.0 International License
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