The Application of Thoracoabdominal Effusion Cell Block Technology in Tumor Origin Diagnosis and Gene Detection of Lung Adenocarcinoma

Min Jiang

Fei Liang

Xiao-Jun Ren

Xiu-Yan Zheng

Huan Li

Yu-Qian Zhang

Abstract

Thoracoabdominal effusion cell block technology is an effective method for cell preservation and fixation, widely used in tumor origin diagnosis and gene detection of lung adenocarcinoma. Based on the principle of cell block fixation, this technology involves collecting cells from thoracoabdominal effusions, followed by centrifugation, fixation, and tissue embedding steps to prepare cell blocks. During diagnosis, pathological analysis of the cell blocks can be performed using techniques such as microscopy,immunohistochemistry, and fluorescence in situ hybridization, aiding in determining the origin of tumors. In lung adenocarcinoma gene detection, thoracoabdominal effusion cell block technology provides a minimally invasive and efficient pathway for genetic testing, helping to understand tumor molecular characteristics,predict treatment responses, and guide personalized therapy. Although this technology has some limitations,with continuous improvement and development, its application prospects in clinical diagnosis and treatment are promising.

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