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Efficacy of the Traditional Chinese Medicine, Qingganhewei Decoction, in Treating Refractory Non-Erosive Reflux Patients with Stagnated Heat in the Liver and Stomach: a Study Protocol for a Prospective Randomized Double-Blind Clinical Trial

Sheng-Nan Zhou （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

Dong-Mei Wang （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

Wei Li （ Department of Gastroenterology,Beijing Hospital of Traditional Chinese MedicineAffliated to Capital Medical University, No. 23 Meishuguan Back Street, Dongcheng District, Beijing 100010, China. ）

Hui-Jie Liu （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

Bao-Li Wang （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

Chen Zhao （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

Xing-Liang Gao （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

Jin-Yue Ding （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

Zhi-Qiang Wang （ Pinggu District Hospital of Traditional Chinese Medicine, No.6 Pingxiang Road, Pinggu District. Beijing 101200, China. ）

https://doi.org/10.37155/2717-5278-0603-4

Abstract

Abstract: Non-erosive refux disease (NERD) is characterized by typical gastroesophageal refux symptoms and the absence of esophageal mucosal damage during upper gastrointestinal endoscopy. Almost 40% of NERD patients who fail to respond to double-dose proton pump inhibitor (PPI) treatment are characterized as having refractory non-erosive reflux (R-NERD). Traditional Chinese medicine (TCM) can effectively relieve the symptoms of this condition. We are conducting a clinical trial to assess the effectiveness of the Qingganhewei decoction in treating R-NERD among patients with stagnated heat in the liver and stomach. Ethics and Discussion: This clinical trial was approved by the Ethics Committee of Pinggu District Hospital of Traditional Chinese Medicine. It is the frst randomized double-blinded trial to compare the effectiveness of the Qingganhewei decoction combined with PPI in treating R-NERD patients with stagnated heat in the liver and stomach. This novel protocol is expected to reduce symptom recurrence, lessen the physical and psychological burden of R-NERD, and provide good social benefts for patients.

Keywords

Refractory non-erosive reflux, protocol, randomized controlled trials, stagnated heat in liver and stomach, qingganhewei decoction

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