间皮瘤的流行病学特征研究现状
马思源 （ 中国医科大学肿瘤医院、辽宁省肿瘤医院病理科 ）
杨 虹 （ 沈阳市第十人民医院病理科 ）
高小卓 （ 中国医科大学肿瘤医院、辽宁省肿瘤医院病理科 ）
石玲玲 （ 中国医科大学肿瘤医院、辽宁省肿瘤医院病理科 ）
李晓波 （ 沈阳医学院病理学教研室 ）
黄 波 （ 中国医科大学肿瘤医院、辽宁省肿瘤医院病理科 ）
Abstract
间皮瘤的发病率虽然远低于相同部位的癌，但因其30~40年的超长潜伏期，很难早期发现诊断，并且与相应部位的恶性肿瘤难以区分，缺乏有效的治疗手段使恶性间皮瘤成为生存期短、死亡率极高的高度恶性肿瘤。近年来随着新发病例逐渐增多，有预测世界范围内将面临爆发的风险。与间皮瘤相关的危险因素包括硅酸盐矿物、猿猴病毒40（SV40）、慢性炎症等，已经明确，但机制性研究延迟于相应部位癌的进展，真实世界中尚缺乏特异性的诊断和靶向治疗指标，导致晚期间皮瘤患者较多且预后较差。本文将从流行病学角度对间皮瘤的危险因素及其机制、流行病学一般特征等加以综述，提高对间皮瘤的发病认识，为进一步寻求间皮瘤的预防、诊断、治疗的措施提供科学依据。
Keywords
间皮瘤; 危险因素; 流行病学; 潜伏期Full Text
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[24]Carbone Michele,Gazdar Adi,Butel Janet S. SV40 and human mesothelioma[J]. Translational lung cancer research. 2020,9(Suppl 1):S47-S59.
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[28]陈忠坚,倪茂巍,毛伟敏.恶性间皮瘤高迁移率蛋白1乙酰化修饰分析[J].肿瘤学杂志, 2016,22(03):194-198.
[29]Wang Yanbin,Jiang Zhaoqiang,Yan Jianing,et al. HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma[J]. Disease markers. 2019,2019:4183157.
[30]Jiaming Xue,Simone Patergnani,Carlotta Giorgi,etal. Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy[J]. Proceedings of the National Academy of Sciences. 2020,117(41):25543-25552.
[31]庞秋华.BAP1与间皮瘤的相关性研究[J].武警后勤学院学报(医学版), 2017,26(10):914-916+920.
[32]李则,任尊,涂鸿鹄,简政,余健秀,邓蓉.BAP1及其抑癌作用研究新进展[J].上海交通大学学报(医学版), 2017,37(05):689-693.
[33]Lai J, Zhou Z, Tang XJ, et al. A Tumor-Specific Neo-Antigen Caused by a Frameshift Mutation in BAP1 Is a Potential Personalized Biomarker in Malignant Peritoneal Mesothelioma[J].Int J Mol Sci. 2016,17(5):739.
[34]Baumann F, Flores E, Napolitano A, etal. Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival[J].Carcinogenesis. 2015,36(1):76-81.
[35]Hung YP, Dong F, Watkins JC, et al. Identification of ALK Rearrangements in Malignant Peritoneal Mesothelioma.JAMA Oncol. 2018;4(2):235-238. doi:10.1001/jamaoncol. 2017,2918
[36]Sato T, Sekido Y. NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.Int J Mol Sci. 2018,19(4):988.
[37]Fernandez-Valle C, Tang Y, Ricard J, et al. Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.Nat Genet. 2002,31(4):354-362.
[38]龚范勇,李希圣,张庆梅,肖绍文.在NF2中Merlin蛋白与Hippo信号通路的相互作用[J].广东医学, 2017,38(12):1927-1930.
[39]Husain AN, Colby TV, Ordóñez NG, etal. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.Arch Pathol Lab Med. 2018;142(1):89-108.
[40]王刚,王世阆.人类肿瘤p16~(INK4a)/CDKN2A基因失活机制及应用[J].浙江肿瘤, 2000(04):248-250.
[41]Keshava Hari B,Tang Andrew,Siddiqui Hafiz Umair,et al. Correction to: Largely Unchanged Annual Incidence and Overall Survival of Pleural Mesothelioma in the USA[J]. World journal of surgery. 2019;43(12):3248.
[42]Britton M. The epidemiology of mesothelioma[J].Semin Oncol. 2002;29(1):18-25.
[43]Consonni D, Migliore E, Barone-Adesi F, et al. Gender differences in pleural mesothelioma occurrence in Lombardy and Piedmont, Italy[J].Environ Res. 2019;177:108636.
[44]徐春生,曹卫华.间皮瘤的流行病学及临床特征[J].职业与健康, 2008,24(23):2588-2590.
[45]曲宸绪,周珊珊,乔友林.我国部分地区胸膜间皮瘤的描述流行病学分析[J].肿瘤研究与临床, 2004(02):143-144.
[46]Robinson BW, Lake RA. Advances in malignant mesothelioma[J].N Engl J Med.2005;353(15):1591-1603.
[47] Jun Zhao,Tingting Zuo,Rongshou Zheng,et al.Epidemiology and trend analysis on malignantmesothelioma in China[J].Chinese Journal of Cancer Research,2017,29(04):361-368.
[48]漆骏,陆荣安,李刚,邢漪,胡黎明.2007-2012年云南省大姚县胸膜间皮瘤死亡分析[J].职业与健康, 2014,30(17):2416-2418.
[49]Liu B, van Gerwen M, Bonassi S, et al. Epidemiology of Environmental Exposure and Malignant Mesothelioma[J].J Thorac Oncol. 2017;12(7):1031-1045.
[50]Marinaccio Alessandro,Binazzi Alessandra,Bonafede Michela,et al. Malignant mesothelioma due to non-occupational asbestos exposure from the Italian national surveillance system (ReNaM): epidemiology and public health issues.[J]. Occupational and environmental medicine. 2015;72(9):648-655.
[51]Lacourt A, Gramond C, Rolland P, et al. Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma[J].Thorax. 2014;69(6):532-539.
[52]Bianchi C, Bianchi T. Malignant mesothelioma: global incidence and relationship with asbestos[J].Ind Health. 2007;45(3):379-387.
[53]黄颖秋.恶性腹膜间皮瘤的诊断和治疗现状[J].世界华人消化杂志, 2017,25(26):2329-2340.
[2]Alpert Naomi,van Gerwen Maaike,Taioli Emanuela. Epidemiology of mesothelioma in the 21stcentury in Europe and the United States, 40 years after restricted/banned asbestos use[J]. Translational lung cancer research. 2020;9(Suppl 1):S28-S38.
[3]Robinson BM. Malignant pleural mesothelioma: an epidemiological perspective[J]. AnnCardiothorac Surg. 2012;1(4):491-496.
[4]Delgermaa V, Takahashi K, Park EK, Le GV, Hara T, Sorahan T. Global mesothelioma deaths reported to the World Health Organization between 1994 and 2008.Bull World Health Organ. 2011;89(10):716-724C.
[5]Odgerel CO, Takahashi K, Sorahan T, etal. Estimation of the global burden of mesothelioma deaths from incomplete national mortality data.Occup Environ Med. 2017;74(12):851-858.
[6]陈凯燕,郭振英,苏丹,毛伟敏.恶性间皮瘤在中国的发病及诊治现状分析[J].中华胸心血管外科杂志, 2017,33(07):443-446.
[7]Price B, Ware A. Time trend of mesothelioma incidence in the United States and projection of future cases: an update based on SEER data for 1973 through 2005[J].Crit Rev Toxicol. 2009;39(7):576-588.
[8]WAGNER JC, SLEGGS CA, MARCHAND P. Diffuse pleural mesothelioma and asbestos exposure in the North Western Cape Province[J].Br J Ind Med. 1960,17(4):260-271.
[9]Wong Jason Y Y,Rice Carol,Blair Aaron,et al. Mesothelioma risk among those exposed to chrysotile asbestos only and mixtures that include amphibole: a case–control study in the USA, 1975–1980[J]. Occupational and Environmental Medicine. 2020;oemed-2020-106665.
[10]David H. Garabrant,Susan T. Pastula. A comparison of asbestos fiber potency and elongate mineral particle (EMP) potency for mesothelioma in humans[J]. Toxicology and Applied Pharmacology. 2018,361:127-136.
[11]Hill RJ, Edwards RE, Carthew P. Early changes in the pleural mesothelium following intrapleural inoculation of the mineral fibre erionite and the subsequent development of mesotheliomas[J].J Exp Pathol (Oxford). 1990,71(1):105-118.
[12]Emory TS, Maddox JC, Kradin RL. Malignant mesothelioma following repeated exposures to cosmetic talc: A case series of 75 patients[J].Am J Ind Med. 2020,63(6):484-489.
[13]Finley BL, Benson SM, Marsh GM. Response to letters regarding "Cosmetic talc as a risk factor for pleural mesothelioma: a weight of evidence evaluation of the epidemiology"[J].Inhal Toxicol. 2018,30(1):1-4.
[14]Attanoos RL, Churg A, Galateau-Salle F, et al. Malignant Mesothelioma and Its Non-Asbestos Causes[J].Arch Pathol Lab Med. 2018;142(6):753-760.
[15]樊晶光,王起恩.石棉的理化特性与其致癌性关系的研究概况[J].工业卫生与职业病, 1996(06):374-378.
[16]龙耀庭,邵巧云,王怡中.石棉纤维表面所附着的Fe,Mg离子对5,6-二羟基-5,6-二氢胸腺嘧啶生成的影响[J].环境化学, 1996(03):248-253.
[17]Gaudino G, Xue J, Yang H. How asbestos and other fibers cause mesothelioma[J].Transl Lung Cancer Res. 2020,9(Suppl 1):S39-S46.
[18]Yang H, Testa JR, Carbone M. Mesothelioma epidemiology, carcinogenesis, and pathogenesis[J].Curr Treat Options Oncol. 2008,9(2-3):147-157.
[19]霍婷婷,董发勤,邓建军,彭同江,秦凯,罗薇,孙东平.蛇纹石石棉纤维表面活性及生物持久性研究进展[J].硅酸盐学报, 2016,44(05):763-768.
[20]王玉琳,邓建军,杨洁,霍婷婷,董发勤.石棉致细胞毒性的氧化应激机制的研究进展[J].环境与职业医学, 2017,34(08):734-739.
[21]Cardile V, Renis M, Scifo C, etal. Behaviour of the new asbestos amphibole fluor-edenite in different lung cell systems[J].Int J Biochem Cell Biol. 2004;36(5):849-860.
[22]吴卫东,刘树春.沸石及其危害[J].国外医学(卫生学分册), 1989(06):321-324.
[23]Carbone M, Pass HI, Rizzo P, et al. Simian virus 40-like DNA sequences in human pleural mesothelioma[J].Oncogene. 1994,9(6):1781-1790.
[24]Carbone Michele,Gazdar Adi,Butel Janet S. SV40 and human mesothelioma[J]. Translational lung cancer research. 2020,9(Suppl 1):S47-S59.
[25]付雨菲,韩丹.胸膜间皮瘤病因及发病机理研究进展[J].湖北科技学院学报(医学版), 2013,27(01):90-92.
[26]金木兰,李雪,罗静,赵宏颖,刘洋.恶性间皮瘤可能与致瘤性猿猴病毒SV40无关[J].中华病理学杂志, 2006(10):602-605.
[27]Pellegrini Laura,Xue Jiaming,Larson David,et al. HMGB1 targeting by ethyl pyruvate suppresses malignant phenotype of human mesothelioma[J]. Oncotarget. 2017;8(14):22649-22661.
[28]陈忠坚,倪茂巍,毛伟敏.恶性间皮瘤高迁移率蛋白1乙酰化修饰分析[J].肿瘤学杂志, 2016,22(03):194-198.
[29]Wang Yanbin,Jiang Zhaoqiang,Yan Jianing,et al. HMGB1 as a Potential Biomarker and Therapeutic Target for Malignant Mesothelioma[J]. Disease markers. 2019,2019:4183157.
[30]Jiaming Xue,Simone Patergnani,Carlotta Giorgi,etal. Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy[J]. Proceedings of the National Academy of Sciences. 2020,117(41):25543-25552.
[31]庞秋华.BAP1与间皮瘤的相关性研究[J].武警后勤学院学报(医学版), 2017,26(10):914-916+920.
[32]李则,任尊,涂鸿鹄,简政,余健秀,邓蓉.BAP1及其抑癌作用研究新进展[J].上海交通大学学报(医学版), 2017,37(05):689-693.
[33]Lai J, Zhou Z, Tang XJ, et al. A Tumor-Specific Neo-Antigen Caused by a Frameshift Mutation in BAP1 Is a Potential Personalized Biomarker in Malignant Peritoneal Mesothelioma[J].Int J Mol Sci. 2016,17(5):739.
[34]Baumann F, Flores E, Napolitano A, etal. Mesothelioma patients with germline BAP1 mutations have 7-fold improved long-term survival[J].Carcinogenesis. 2015,36(1):76-81.
[35]Hung YP, Dong F, Watkins JC, et al. Identification of ALK Rearrangements in Malignant Peritoneal Mesothelioma.JAMA Oncol. 2018;4(2):235-238. doi:10.1001/jamaoncol. 2017,2918
[36]Sato T, Sekido Y. NF2/Merlin Inactivation and Potential Therapeutic Targets in Mesothelioma.Int J Mol Sci. 2018,19(4):988.
[37]Fernandez-Valle C, Tang Y, Ricard J, et al. Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology.Nat Genet. 2002,31(4):354-362.
[38]龚范勇,李希圣,张庆梅,肖绍文.在NF2中Merlin蛋白与Hippo信号通路的相互作用[J].广东医学, 2017,38(12):1927-1930.
[39]Husain AN, Colby TV, Ordóñez NG, etal. Guidelines for Pathologic Diagnosis of Malignant Mesothelioma 2017 Update of the Consensus Statement From the International Mesothelioma Interest Group.Arch Pathol Lab Med. 2018;142(1):89-108.
[40]王刚,王世阆.人类肿瘤p16~(INK4a)/CDKN2A基因失活机制及应用[J].浙江肿瘤, 2000(04):248-250.
[41]Keshava Hari B,Tang Andrew,Siddiqui Hafiz Umair,et al. Correction to: Largely Unchanged Annual Incidence and Overall Survival of Pleural Mesothelioma in the USA[J]. World journal of surgery. 2019;43(12):3248.
[42]Britton M. The epidemiology of mesothelioma[J].Semin Oncol. 2002;29(1):18-25.
[43]Consonni D, Migliore E, Barone-Adesi F, et al. Gender differences in pleural mesothelioma occurrence in Lombardy and Piedmont, Italy[J].Environ Res. 2019;177:108636.
[44]徐春生,曹卫华.间皮瘤的流行病学及临床特征[J].职业与健康, 2008,24(23):2588-2590.
[45]曲宸绪,周珊珊,乔友林.我国部分地区胸膜间皮瘤的描述流行病学分析[J].肿瘤研究与临床, 2004(02):143-144.
[46]Robinson BW, Lake RA. Advances in malignant mesothelioma[J].N Engl J Med.2005;353(15):1591-1603.
[47] Jun Zhao,Tingting Zuo,Rongshou Zheng,et al.Epidemiology and trend analysis on malignantmesothelioma in China[J].Chinese Journal of Cancer Research,2017,29(04):361-368.
[48]漆骏,陆荣安,李刚,邢漪,胡黎明.2007-2012年云南省大姚县胸膜间皮瘤死亡分析[J].职业与健康, 2014,30(17):2416-2418.
[49]Liu B, van Gerwen M, Bonassi S, et al. Epidemiology of Environmental Exposure and Malignant Mesothelioma[J].J Thorac Oncol. 2017;12(7):1031-1045.
[50]Marinaccio Alessandro,Binazzi Alessandra,Bonafede Michela,et al. Malignant mesothelioma due to non-occupational asbestos exposure from the Italian national surveillance system (ReNaM): epidemiology and public health issues.[J]. Occupational and environmental medicine. 2015;72(9):648-655.
[51]Lacourt A, Gramond C, Rolland P, et al. Occupational and non-occupational attributable risk of asbestos exposure for malignant pleural mesothelioma[J].Thorax. 2014;69(6):532-539.
[52]Bianchi C, Bianchi T. Malignant mesothelioma: global incidence and relationship with asbestos[J].Ind Health. 2007;45(3):379-387.
[53]黄颖秋.恶性腹膜间皮瘤的诊断和治疗现状[J].世界华人消化杂志, 2017,25(26):2329-2340.
Copyright © 2021 马思源, 杨 虹, 高小卓, 石玲玲, 李晓波, 黄 波
Publishing time:2021-06-30
This work is licensed under a Creative Commons Attribution 4.0 International License
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