雷贝拉唑联合胃复春片用于消化性溃疡的临床效果及对血清VEGF、LPO、SOD、NO的影响
季文媛
卫佳琪
刘炜 （ 首都医科大学附属北京世纪坛医院 ）
Abstract
摘要：目的：研究雷贝拉唑联合胃复春片用于消化性溃疡的临床效果及对血清血管内皮生长因子（VEGF）、过氧化脂质（LPO）、超氧化物歧化酶（SOD）、一氧化氮（NO）的影响。方法：选取2015年9月至2016年8月我院收治的62例消化性溃疡患者，根据患者入院顺序分为观察组和对照组，31例每组。对照组使用雷贝拉唑钠肠溶片完成治疗，观察组加以胃复春片完成治疗。比较两组临床疗效，血清VEGF、LPO、SOD、NO水平，临床症状评分。结果：治疗后，观察组临床总有效率显著高于对照组[90.32%（28/31）比64.52%（20/31）]（P < 0.05）。 治疗前，两组患者呃逆暖气、畏寒肢体、倦怠乏力、便溏、纳呆食少、脘腹胀满、胃脘痛临床症状评分比较无显著差异（P > 0.05），治疗后，两组患者呃逆暖气、畏寒肢体、倦怠乏力、便溏、纳呆食少、脘腹胀满、胃脘痛临床症状评分较治疗前显著降低（P < 0.05），和对照组相比，观察组的呃逆暖气、畏寒肢体、倦怠乏力、便溏、纳呆食少、脘腹胀满、胃脘痛临床症状评分较低（P < 0.05）。治疗前，两组患者血清VEGF、LPO、SOD、NO水平比较无显著差异（P > 0.05），治疗后，和治疗前相比，两组患者血清LPO水平显著降低（P < 0.05），VEGF、SOD、NO水平显著上升（P < 0.05），和对照组相比，观察组的血清LPO水平较低（P < 0.05），VEGF、SOD、NO水平较高（P < 0.05）。结论：雷贝拉唑联合胃复春片用于消化性溃疡，能有效降低患者LPO水平，升高VEGF、SOD、NO水平，临床疗效良好。
Keywords
雷贝拉唑; 胃复春片; 消化性溃疡Full Text
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[1]Xiao X, Lau JY. Over-the-scope clip treatment of refractory peptic ulcer bleeding[J]. Gastrointestinal endoscopy, 2016,83(2):458-459.
[2]Vester-Andersen M, Lundstrøm LH, Buck DL, et al. Association between surgical delay and survival in high-risk emergency abdominal surgery. A population-based Danish cohort study[J]. Scandinavian journal of gastroenterology, 2016,51(1):121-128.
[3]Kärkkäinen JM, Miilunpohja S, Rantanen T, et al. Alcohol Abuse Increases Rebleeding Risk and Mortality in Patients with Non-variceal Upper Gastrointestinal Bleeding[J]. Digestive diseases and sciences, 2015,60(12):3707-3715.
[4]Desai V, Gonda D, Ryan SL, et al. The effect of weekend and after-hours surgery on morbidity and mortality rates in pediatric neurosurgery patients[J]. Pediatrics, 2015,16(6):726-731.
[5]Realo A, Teras A, Kööts-Ausmees L, et al. The relationship between the Five-Factor Model personality traits and peptic ulcer disease in a large population-based adult sample[J]. Scandinavian journal of psychology, 2015,56(6):693-699.
[6]Chang SS, Hu HY. Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens[J]. World journal of gastrointestinal pharmacology and therapeutics, 2015,6(4):127-136.
[7]Alimadadi M, Seyyedmajidi M, Amirkhanlou S,et al. Impact of Creatinine Clearance on Helicobacter Pylori Eradication Rate in Patients With Peptic Ulcer Disease[J]. Iranian journal of kidney diseases, 2015,9(6):427-432.
[8]Murata A, Mayumi T, Muramatsu K, et al. Effect of dementia on outcomes of elderly patients with hemorrhagic peptic ulcer disease based on a national administrative database[J]. Aging clinical and experimental research, 2015,27(5):717-725.
[9]Paudel MS, Kc S, Mandal AK, et al. Acute Upper Gastrointestinal Bleeding in a Tertiary Care Centre of Nepal[J]. JNMA J Nepal Med Assoc, 2017,56(206):211-216.
[10]Minalyan A, Gabrielyan L, Scott D,et al. The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors[J]. Curr Gastroenterol Rep, 2017,19(8):42.
[11]Li H, Yang T, Liao T, et al. Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains[J]. Microb Cell, 2017,4(5):175-178.
[12]Triantos C, Kalafateli M, Spantidea PI,et al. Bacterial load and cytokine profile in patients with cirrhosis following therapy with proton pump inhibitors: a prospective cohort study[J]. Ann Gastroenterol, 2017,30(4):450-456.
[13]Ghosh CK, Khan MR, Alam F, et al. Peptic Ulcer Disease in Bangladesh: A Multi-centre Study[J]. Mymensingh Med J, 2017,26(1):141-144.
[14]Jang JY. Recent Developments in the Endoscopic Treatment of Patients with Peptic Ulcer Bleeding[J]. Clin Endosc, 2016,49(5):417-420.
[15]Chen H, Olatunji OJ, Zhou Y. Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice[J]. J Nat Med, 2016,70(3):610-619.
[16]Li LF, Chan RL, Lu L, et al. Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review)[J]. Int J Mol Med, 2014,34(2):372-380.
[17]Song DU, Jang MS, Kim HW, et al. Gastroprotective Effects of Glutinous Rice Extract against Ethanol-, Indomethacin-, and Stress-induced Ulcers in Rats[J]. Chonnam Med J, 2014,50(1):6-14.
[18]Sachs G, Shin JM, Munson K, et al. Gastric acid-dependent diseases: a twentieth-century revolution[J]. Dig Dis Sci, 2014,59(7):1358-1369.
[19]Machado-Alba JE, Castrillón-Spitia JD, Londoño-Builes MJ, et al. An economic analysis of inadequate prescription of antiulcer medications for in-hospital patients at a third level institution in Colombia[J]. Rev Esp Enferm Dig, 2014,106(2):77-85.
[20]Carr WR, Mahawar KK, Balupuri S, et al. An evidence-based algorithm for the management of marginal ulcers following Roux-en-Y gastric bypass[J]. Obes Surg, 2014,24(9):1520-1527.
[21]Bercovich E, Keinan-Boker L, Shasha SM. Long-term health effects in adults born during the Holocaust[J]. Isr Med Assoc J, 2014,16(4):203-207.
[22]Graham DY. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer[J]. World J Gastroenterol, 2014,20(18):5191-5204.
[23]Chey WD, Leontiadis GI, Howden CW, et al. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection[J]. Am J Gastroenterol, 2017,112(2):212-239.
[24]Dorajoo SR, See V, Chan CT, et al. Identifying Potentially Avoidable Readmissions: A Medication-Based 15-Day Readmission Risk Stratification Algorithm[J]. Pharmacotherapy, 2017,37(3):268-277.
[25]Amouei A, Ehsani F, Zarch MB, et al. Peritonitis Following Duodenal Ulcer Perforation in a Newborn: A Case Report[J]. J Clin Diagn Res, 2016,10(11):PD10-PD11.
[26]Ha X, Peng J, Zhao H, et al. Enhancement of Gastric Ulcer Healing and Angiogenesis by Hepatocyte Growth Factor Gene Mediated by Attenuated Salmonella in Rats[J]. J Korean Med Sci, 2017,32(2):186-194.
[27]Goyal R, Debi U, Dey P, et al. Zollinger-Ellison syndrome: an unusual case of chronic diarrhoea in a child[J]. Malays J Pathol, 2016,38(3):321-325.
[28]Zhou LY, Song ZQ, Xue Y, et al. Recurrence of Helicobacter pylori infection and the affecting factors: A follow-up study[J]. J Dig Dis, 2017,18(1):47-55.
[29]Kwiecien S, Magierowska K, Magierowski M, et al. Role of sensory afferent nerves, lipid peroxidation and antioxidative enzymes in the carbon monoxide-induced gastroprotection against stress ulcerogenesis[J]. J Physiol Pharmacol, 2016,67(5):717-729.
[30]Lee S, Jeong S, Kim W,et al. Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase[J]. Biochem Biophys Res Commun, 2017,483(1):449-455.
[2]Vester-Andersen M, Lundstrøm LH, Buck DL, et al. Association between surgical delay and survival in high-risk emergency abdominal surgery. A population-based Danish cohort study[J]. Scandinavian journal of gastroenterology, 2016,51(1):121-128.
[3]Kärkkäinen JM, Miilunpohja S, Rantanen T, et al. Alcohol Abuse Increases Rebleeding Risk and Mortality in Patients with Non-variceal Upper Gastrointestinal Bleeding[J]. Digestive diseases and sciences, 2015,60(12):3707-3715.
[4]Desai V, Gonda D, Ryan SL, et al. The effect of weekend and after-hours surgery on morbidity and mortality rates in pediatric neurosurgery patients[J]. Pediatrics, 2015,16(6):726-731.
[5]Realo A, Teras A, Kööts-Ausmees L, et al. The relationship between the Five-Factor Model personality traits and peptic ulcer disease in a large population-based adult sample[J]. Scandinavian journal of psychology, 2015,56(6):693-699.
[6]Chang SS, Hu HY. Helicobacter pylori: Effect of coexisting diseases and update on treatment regimens[J]. World journal of gastrointestinal pharmacology and therapeutics, 2015,6(4):127-136.
[7]Alimadadi M, Seyyedmajidi M, Amirkhanlou S,et al. Impact of Creatinine Clearance on Helicobacter Pylori Eradication Rate in Patients With Peptic Ulcer Disease[J]. Iranian journal of kidney diseases, 2015,9(6):427-432.
[8]Murata A, Mayumi T, Muramatsu K, et al. Effect of dementia on outcomes of elderly patients with hemorrhagic peptic ulcer disease based on a national administrative database[J]. Aging clinical and experimental research, 2015,27(5):717-725.
[9]Paudel MS, Kc S, Mandal AK, et al. Acute Upper Gastrointestinal Bleeding in a Tertiary Care Centre of Nepal[J]. JNMA J Nepal Med Assoc, 2017,56(206):211-216.
[10]Minalyan A, Gabrielyan L, Scott D,et al. The Gastric and Intestinal Microbiome: Role of Proton Pump Inhibitors[J]. Curr Gastroenterol Rep, 2017,19(8):42.
[11]Li H, Yang T, Liao T, et al. Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains[J]. Microb Cell, 2017,4(5):175-178.
[12]Triantos C, Kalafateli M, Spantidea PI,et al. Bacterial load and cytokine profile in patients with cirrhosis following therapy with proton pump inhibitors: a prospective cohort study[J]. Ann Gastroenterol, 2017,30(4):450-456.
[13]Ghosh CK, Khan MR, Alam F, et al. Peptic Ulcer Disease in Bangladesh: A Multi-centre Study[J]. Mymensingh Med J, 2017,26(1):141-144.
[14]Jang JY. Recent Developments in the Endoscopic Treatment of Patients with Peptic Ulcer Bleeding[J]. Clin Endosc, 2016,49(5):417-420.
[15]Chen H, Olatunji OJ, Zhou Y. Anti-oxidative, anti-secretory and anti-inflammatory activities of the extract from the root bark of Lycium chinense (Cortex Lycii) against gastric ulcer in mice[J]. J Nat Med, 2016,70(3):610-619.
[16]Li LF, Chan RL, Lu L, et al. Cigarette smoking and gastrointestinal diseases: the causal relationship and underlying molecular mechanisms (review)[J]. Int J Mol Med, 2014,34(2):372-380.
[17]Song DU, Jang MS, Kim HW, et al. Gastroprotective Effects of Glutinous Rice Extract against Ethanol-, Indomethacin-, and Stress-induced Ulcers in Rats[J]. Chonnam Med J, 2014,50(1):6-14.
[18]Sachs G, Shin JM, Munson K, et al. Gastric acid-dependent diseases: a twentieth-century revolution[J]. Dig Dis Sci, 2014,59(7):1358-1369.
[19]Machado-Alba JE, Castrillón-Spitia JD, Londoño-Builes MJ, et al. An economic analysis of inadequate prescription of antiulcer medications for in-hospital patients at a third level institution in Colombia[J]. Rev Esp Enferm Dig, 2014,106(2):77-85.
[20]Carr WR, Mahawar KK, Balupuri S, et al. An evidence-based algorithm for the management of marginal ulcers following Roux-en-Y gastric bypass[J]. Obes Surg, 2014,24(9):1520-1527.
[21]Bercovich E, Keinan-Boker L, Shasha SM. Long-term health effects in adults born during the Holocaust[J]. Isr Med Assoc J, 2014,16(4):203-207.
[22]Graham DY. History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer[J]. World J Gastroenterol, 2014,20(18):5191-5204.
[23]Chey WD, Leontiadis GI, Howden CW, et al. ACG Clinical Guideline: Treatment of Helicobacter pylori Infection[J]. Am J Gastroenterol, 2017,112(2):212-239.
[24]Dorajoo SR, See V, Chan CT, et al. Identifying Potentially Avoidable Readmissions: A Medication-Based 15-Day Readmission Risk Stratification Algorithm[J]. Pharmacotherapy, 2017,37(3):268-277.
[25]Amouei A, Ehsani F, Zarch MB, et al. Peritonitis Following Duodenal Ulcer Perforation in a Newborn: A Case Report[J]. J Clin Diagn Res, 2016,10(11):PD10-PD11.
[26]Ha X, Peng J, Zhao H, et al. Enhancement of Gastric Ulcer Healing and Angiogenesis by Hepatocyte Growth Factor Gene Mediated by Attenuated Salmonella in Rats[J]. J Korean Med Sci, 2017,32(2):186-194.
[27]Goyal R, Debi U, Dey P, et al. Zollinger-Ellison syndrome: an unusual case of chronic diarrhoea in a child[J]. Malays J Pathol, 2016,38(3):321-325.
[28]Zhou LY, Song ZQ, Xue Y, et al. Recurrence of Helicobacter pylori infection and the affecting factors: A follow-up study[J]. J Dig Dis, 2017,18(1):47-55.
[29]Kwiecien S, Magierowska K, Magierowski M, et al. Role of sensory afferent nerves, lipid peroxidation and antioxidative enzymes in the carbon monoxide-induced gastroprotection against stress ulcerogenesis[J]. J Physiol Pharmacol, 2016,67(5):717-729.
[30]Lee S, Jeong S, Kim W,et al. Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5'-AMP-activated protein kinase[J]. Biochem Biophys Res Commun, 2017,483(1):449-455.
Copyright © 2019 季文媛，卫佳琪，刘炜
Publishing time:2019-09-30
This work is licensed under a Creative Commons Attribution 4.0 International License
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