成纤维细胞生长因子23与终末期肾病患者并发症相关

姒雨禾 ( 浙江中医药大学 )

谢海英* ( 绍兴市人民医院肾内科 )

官继超 ( 绍兴市人民医院肾内科 )

龚淑文 ( 绍兴市人民医院肾内科 )

沈水娟 ( 绍兴市人民医院肾内科 )

https://doi.org/10.37155/2661-4766-0605-60

Abstract

成纤维细胞生长因子23(FGF23)是钙磷代谢的重要调节因子,主要由骨细胞和成骨细胞分泌。FGF23 在甲状旁腺轴中起重要作用,参与调控骨矿物质代谢,通过作用于肾组织中的受体复合物Klotho调节钙磷代谢,参与 终末期肾病患者矿物代谢和肾性骨病,也与血管钙化,心血管事件等有关,FGF23还与促红细胞生成素、铁代谢、炎 症存在双向作用,这使得FGF23在肾性贫血,感染等方面中也发挥重要作用,有望成为治疗新靶点。

Keywords

成纤维细胞生长因子23;终末期肾病;血管钙化;贫血;炎症

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Copyright © 2024 姒雨禾,谢海英*,官继超,龚淑文,沈水娟 Creative Commons License Publishing time:2024-10-31
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