脂溶性维生素对糖尿病肾病的作用研究进展
邝洋洋 （ 中国医科大学 ）
王晓聪 （ 中国医科大学 ）
https://doi.org/10.37155/2661-4766-0704-17Abstract
糖尿病肾病（Diabetic Nephropathy，DN）是糖尿病的最主要并发症之一，也是终末期肾脏疾病的重要 病因。DN是由于糖尿病患者长期处于较高水平的血糖而导致的尿蛋白持续升高和肾小球滤过率进行性降低，随着肾 脏功能的逐步恶化，将严重影响患者的预后和生活质量。脂溶性维生素是不溶于水而溶于脂肪和非极性有机溶剂的必 需营养素，其在DN发生发展过程中发挥一定程度的保护作用。本文主要围绕脂溶性维生素对DN的影响及疗效展开介 绍，综述了脂溶性维生素对DN的治疗潜力，旨在为DN的防治策略提供安全和崭新的思路，以期为DN患者提供更加 安全有效的治疗途径。
Keywords
糖尿病肾病；脂溶性维生素；糖尿病并发症Full Text
PDFReferences
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Kidney Disease in Patients With Type 2 Diabetes in China:
Cross-Sectional Study. JMIR Public Health Surveill, 2024. 10:
p. e54429.
[2]Selby, N.M. and M.W. Taal, An updated overview of
diabetic nephropathy: Diagnosis, prognosis, treatment goals
and latest guidelines. Diabetes Obes Metab, 2020. 22 Suppl 1:
p. 3-15.
[3]Zhou, J., et al., Nutritional Strategies against Diabetic
Nephropathy: Insights from Animal Studies and Human
Trials. Nutrients, 2024. 16(12).
[4]张云琪,et al.,糖尿病并发症发病机制及治疗药物研
究进展.中国药理学通报,2024.40(10):p.1808-1813.
[5]Kim, C.S., et al., All-Trans Retinoic Acid Has a
Potential Therapeutic Role for Diabetic Nephropathy. Yonsei
Med J, 2015. 56(6): p. 1597-603.
[6]陈春琳,全反式维甲酸调节糖尿病大鼠肾脏ACE/
ACE2表达抑制肾脏纤维化的研究.2016.
[7]Han, S.Y., et al., Effect of retinoic acid in experimental
diabetic nephropathy. Immunol Cell Biol, 2004. 82(6): p. 568-76.
[8]李英楠,全反式维甲酸对肾小球足细胞保护作用的
研究.现代中西医结合杂志,2012.21(34):p.3869-3871.
[9]Huang, H.Y., et al., Vitamin D and Diabetic Kidney
Disease. Int J Mol Sci, 2023. 24(4).
[10]Nakai, K., et al., Vitamin D activates the Nrf2-Keap1
antioxidant pathway and ameliorates nephropathy in diabetic
rats. Am J Hypertens, 2014. 27(4): p. 586-95.
[11]Lei, M., Z. Liu, and J. Guo, The Emerging Role of
Vitamin D and Vitamin D Receptor in Diabetic Nephropathy.
Biomed Res Int, 2020. 2020: p. 4137268.
[12]Khatami, P.G., et al., The effects of high-dose
vitamin E supplementation on biomarkers of kidney injury,
inflammation, and oxidative stress in patients with diabetic
nephropathy: A randomized, double-blind, placebo-controlled
trial. J Clin Lipidol, 2016. 10(4): p. 922-929.
[13]Haghighat, N., et al., The Effects of Tocotrienols
Added to Canola Oil on Microalbuminuria, Inflammation,
and Nitrosative Stress in Patients with Type 2 Diabetes: A
Randomized, Double-blind, Placebo-controlled Trial. Int J
Prev Med, 2014. 5(5): p. 617-23.
[14]Zhao, Y., et al., High Dose Vitamin E Attenuates
Diabetic Nephropathy via Alleviation of Autophagic Stress.
Front Physiol, 2018. 9: p. 1939.
[15]Hayashi, D., et al., Diacylglycerol Kinase alpha is
Involved in the Vitamin E-Induced Amelioration of Diabetic
Nephropathy in Mice. Sci Rep, 2017. 7(1): p. 2597.
[16]Roumeliotis, S., et al., The Association of dp-ucMGP
with Cardiovascular Morbidity and Decreased Renal Function
in Diabetic Chronic Kidney Disease. Int J Mol Sci, 2020. 21(17).
[17]Kurnatowska, I., et al., Effect of vitamin K2 on
progression of atherosclerosis and vascular calcification in
nondialyzed patients with chronic kidney disease stages 3-5.
Pol Arch Med Wewn, 2015. 125(9): p. 631-40.
[18]Sai Varsha, M.K., et al., Hypoglycemic action of
vitamin K1 protects against early-onset diabetic nephropathy
in streptozotocin-induced rats. Nutrition, 2015. 31(10): p.
1284-92.
Copyright © 2025 邝洋洋,王晓聪
Publishing time:2025-08-31
This work is licensed under a Creative Commons Attribution 4.0 International License
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