C-反应蛋白和降钙素原在儿童支气管肺炎中的联合诊断价值

程 松 ( 西南医科大学附属医院医学检验部 )

赵素蓉 ( 成都新华医院 )

闻丽莎 ( 泸州市江阳区妇幼保健院计划生育服务中心 )

https://doi.org/10.37155/2661-4766-0401-40

Abstract

目的: 探讨C-反应蛋白( CRP)和降钙素原( PCT)在儿童支气管肺炎中的联合诊断价值。 方法: 我院 收治的257例患支气管肺炎的儿童作为感染组,同时选取我院42名健康儿童作为同期健康对照组。检测出感染组和健 康对照组的CRP及PCT浓度值,用单因素方差( one-way ANOVA)进行分析,比较感染组和健康对照组两组间CRP和 PCT值的变化;使用SPSS 17. 0软件进行绘制,分别得出CRP和PCT诊断儿童支气管肺炎的受试者工作曲线(ROC曲 线),计算出CRP和PCT的AUC,即曲线下面积;然后分析ROC曲线,得出CRP, PCT单项诊断儿童支气管肺炎以及 CRP和PCT联合诊断儿童支气管肺炎的敏感度和特异性,判断单项检测和联合检测的诊断价值。 结果: 与健康组作比 较后发现, CRP和PCT在支气管肺炎患儿中均显著升高, CRP单独诊断儿童支气管肺炎的AUC为0.608,敏感度和特异 度为0.693 和0.405; PCT单独诊断儿童支气管肺炎的AUC为0.900,敏感度和特异度为0.996和0.143, CRP和PCT联合诊 断支气管肺炎的AUC为0.674,联合诊断的敏感度和特异度分别为0.996和0.095。 结论: CRP和PCT分别对儿童支气管 肺炎具有一定的诊断价值。二者联合对儿童支气管肺炎的诊断有一定的应用价值。

Keywords

C-反应蛋白;降钙素原;儿童支气管肺炎;诊断价值

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