糖尿病与眼表螨虫感染的相关研究进展
黄 畅 （ 南方医科大学珠江医院 ）
李振豪 （ 南方医科大学珠江医院 ）
李思琪 （ 南方医科大学珠江医院 ）
符 敏 （ 南方医科大学珠江医院 ）
李海量 （ 广东省第二人民医院 ）
易果果 （ 中山大学附属第六医院 ）
https://doi.org/10.37155/2661-4766-0206-3Abstract
眼表螨虫感染是一种常见的眼部寄生虫疾病，眼表螨虫感染患者常有眼干，眼烧灼感、异物感、畏光及倒睫等临床症状，严重危害患者身心健康和生活质量。据研究发现，糖尿病患者眼表螨虫感染率较正常人高，而随着糖尿病发病率的逐年升高，使得眼表螨虫感染也随之升高，使其成为危害糖尿病患者眼部正常功能的疾病之一。目前由糖尿病眼表螨虫感染的机制尚不明确，治疗方法单一匮乏、尚无统一标准，对患者的预后亦缺乏临床数据。本文就糖尿病和眼表螨虫感染近年来的研究进行总结和分析，以期为临床诊治和进一步机制探讨提供参考。
Keywords
蠕形螨; 眼表微环境; 眼表疾病; 糖尿病Full Text
PDFReferences
[1]Yamashita,L.S.,et al.,Demodex folliculorum on the eyelash follicle of diabetic patients.Arq Bras Oftalmol, 2011.74(6):p.422-4.
[2]Arli,C.,et al.,The Incidence of Demodex folliculorum in the Combination of Allergic Rhinitis and Diabetes Mellitus.Iran J Parasitol, 2019.14(3):p.459-464.
[3]Ferrer L,Ravera I,Silbermayr K.Immunology and pathogenesis of canine demodicosis[J].Veterinary Dermatology, 2014,25(5):427-465.
[4]Rufli T,Mumcuoglu Y.The hair follicle mites Demodex folliculorum and Demodex brevis:biology and medical importance.A review[J].Dermatology, 1981,162(1):1-11.
[5]Nicholls S G,Oakley C L,Tan A,et al.Demodex species in human ocular disease:new clinicopathological aspects[J].Int Ophthalmol, 2017,37(1):303-312.
[6]Elston C A,Elston D M.Demodex mites[J].Clinics in Dermatology, 2014,32(6):739-743.
[7]Bhandari V,Reddy J K.Blepharitis:always remember demodex.[J].Middle East African Journal of Ophthalmology, 2014,21(4):317.
[8]高莹莹,许锻炼,黄丽娟,王蓉.睑缘鳞屑与眼睑蠕形螨寄居关系的临床分析[J].中华眼科杂志, 2009,45(9):834-835.
[9]Kim J T,Lee S H,Chun Y S,et al.Tear cytokines and chemokines in patients with Demodex blepharitis[J].Cytokine, 2011,53(1):94-99.
[10]Keskin,K.R.,et al.,Increased density of Demodex folliculorum mites in pregnancies with gestational diabetes.Med Princ Pract, 2014.23(4):p.369-72.
[11]Randon M,Liang H,El H M,et al.In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation.[J].Br J Ophthalmol, 2015,99(3):336-341.
[12]梁凌毅,李晶,刘艳.对蠕形螨致睑缘炎诊断中问题的思考[J].中华眼科杂志, 2017,53(9).
[13]Rodríguez A E,Ferrer C,AlióJ L.[Chronic blepharitis and Demodex][J].Archivos De La Sociedad Espanola De Oftalmologia, 2005,80(11):635.
[14]Gao Y Y,Pascuale M A D,Li W,et al.In vitro and in vivo killing of ocular Demodex by tea tree oil.[J].British Journal of Ophthalmology, 2005,89(89):1468-1473.
[15]Halcón L,Milkus K.Staphylococcus aureus and wounds:a review of tea tree oil as a promising antimicrobial.[J].American Journal of Infection Control, 2004,32(7):402-408.
[16]柯兰,杨燕宁,黄林英,王宇静,汪波,李经纬.妥布霉素地塞米松眼膏联合茶树油治疗蠕形螨性睑缘炎的观察[J].中华眼视光学与视觉科学杂志, 2017,19(3):176-181.
[17]Gökçe,C.,et al.,The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus.J Int Med Res,2013.41(5):p.1752-8.
[18]Salem D A,Elshazly A,Nabih N,et al.Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum.[J].International Journal of Infectious Diseases Ijid Official Publication of the International Society for Infectious Diseases, 2013,17(5):e343.
[19]Xu Y,Wang L,He J,et al.Prevalence and Control of Diabetes in Chinese Adults[J].Journal of the American Medical Association, 2013,310(9):948-959.
[20]Xu Y,Wang L,He J,et al.Prevalence and control of diabetes in Chinese adults.[J].Jama the Journal of the American Medical Association, 2013,310(9):948-959.
[21]Clifford C W,Fulk G W.Association of Diabetes,Lash Loss,and Staphylococcus aureus with Infestation of Eyelids by Demodex folliculorum(Acari:Demodicidae)[J].Journal of Medical Entomology, 1990,27(4):467-470.
[22]Ünal,E.,A.U.Güvendi and A.Arduç,Hidradenitis Suppurativa,Metabolic Syndrome,and Demodex spp.Infestation.Turkiye Parazitol Derg, 2018.42(2):p.171-174.
[23]Gökçe C,Aycan-KayaÖ,Yula E,et al.The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus[J].J Int Med Res., 2013,41(5):1752-1758.
[24]Yamashita L S,Cariello A J,Geha N M,et al.Demodex folliculorum on the eyelash follicule of diabetic patients[J].Arquivos Brasileiros De Oftalmologia, 2011,74(6):422-424.
[25]Cengiz Z T,Ozkol H U,Beyhan Y E,et al.Evaluation of some chronical diseases in etiopathogenesis of demodicosis[J].Dermatologica Sinica, 2017.
[26]Yagdiran D O,Aytekin S.Comparison of Demodex folliculorum density in haemodialysis patients with a control group.[J].Journal of the European Academy of Dermatology&Venereology Jeadv, 2007,21(4):480.
[27]Nara T,Katoh N,Inoue K,et al.Eosinophilic folliculitis with a Demodex folliculorum infestation successfully treated with ivermectin in a man infected with human immunodeficiency virus[J].Clinical&Experimental Dermatology, 2009,34(8):e981-e983.
[28]Chang H N.[Chemotaxis of blood monocytes and polymorphonuclear leukocytes from patients with diabetes mellitus][J].Zhonghua Minguo wei sheng wu xue za zhi=Chinese journal of microbiology, 1979,12(4):136-139.
[29]Bagdade J D,Nielson K L,Bulger R J.Reversible abnormalities in phagocytic function in poorly controlled diabetic patients.[J].American Journal of the Medical Sciences, 1972,263(6):451-456.
[30]Sannomiya P,Oliveira M A,Fortes Z B.Aminoguanidine and the prevention of leukocyte dysfunction in diabetes mellitus:a direct vital microscopic study[J].British Journal of Pharmacology, 1997,122(5):894-898.
[31]Moriguchi P,Sannomiya P,Lara P F,et al.Lymphatic system changes in diabetes mellitus:role of insulin and hyperglycemia[J].Diabetes/metabolism Research&Reviews, 2005,21(2):150-157.
[32]Alba-Loureiro T C,Martins E F,Landgraf R G,et al.Role of insulin on PGE 2 generation during LPS-induced lung inflammation in rats[J].Life Sciences, 2006,78(6):578-585.
[33]Huang Y,Yang B,Li W.Defining the normal"core microbiome"of conjunctival microbial communities[J].Clinical Microbiology&Infection the Official Publication of the European Society of Clinical Microbiology&Infectious Diseases, 2016,22(7):643-647.
[34]Martins E N,Alvarenga L S,Höflinglima A L,et al.Aerobic bacterial conjunctival flora in diabetic patients.[J].Cornea, 2004,23(2):136-142.
[35]Fernández-Rubio M E,Rebolledo-Lara L,Martinez-García M,et al.The conjunctival bacterial pattern of diabetics undergoing cataract surgery[J].Eye, 2010,24(5):825.
[36]Thoemmes M S,Fergus D J,Urban J,et al.Ubiquity and diversity of human-associated Demodex mites[J].Plos One, 2014,9(8):e106265.
[37]Nicholls S G,Oakley C L,Tan A,et al.Demodex species in human ocular disease:new clinicopathological aspects[J].Int Ophthalmol, 2017,37(1):303-312.
[38]Wolf R,Ophir J,Avigad J,et al.The hair follicle mites(Demodex spp.).Could they be vectors of pathogenic microorganisms?[J].Acta dermato-venereologica, 1988,68(6):535-537.
[39]Stephenson J,Fuller J H.Microvascular and acute complications in IDDM patients:the EURODIAB IDDM Complications Study[J].Diabetologia, 1994,37(3):278-285.
[40]Pambianco G,Costacou T,Ellis D,et al.The 30-year natural history of type 1 diabetes complications:the Pittsburgh Epidemiology of Diabetes Complications Study experience[J].Diabetes, 2006,55(5):1463.
[41]Sperling L C.Hair anatomy for the clinician[J].Journal of the American Academy of Dermatology, 1991,25(1 Pt 1):1-17.
[42]Piérard G E,Piérard-Franchimont C,Marks R,et al.EEMCO guidance for the assessment of hair shedding and alopecia[J].Skin Pharmacol Physiol, 2004,17(2):98-110.
[43]Plikus M V,Spyk E N V,Pham K,et al.The circadian clock in skin:implications for adult stem cells,tissue regeneration,cancer,aging,and immunity[J].Journal of Biological Rhythms, 2015,30(3):163.
[44]Hayashi S,Miyamoto I,Takeda K.Measurement of human hair growth by optical microscopy and image analysis.[J].British Journal of Dermatology, 1991,125(2):123.
[45]Andl T,Ahn K,Kairo A,et al.Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development[J].Development, 2004,131(10):2257-2268.
[46]Paus R,Christoph T,Müllerröver S.Immunology of the hair follicle:a short journey into terra incognita.[J].J Investig Dermatol Symp Proc, 1999,4(3):226-234.
[47]Cakmak S,Gül U,Gönül M,et al.Statin therapy and diabetic skin.[J].Advances in Therapy, 2008,25(1):17-22.
[2]Arli,C.,et al.,The Incidence of Demodex folliculorum in the Combination of Allergic Rhinitis and Diabetes Mellitus.Iran J Parasitol, 2019.14(3):p.459-464.
[3]Ferrer L,Ravera I,Silbermayr K.Immunology and pathogenesis of canine demodicosis[J].Veterinary Dermatology, 2014,25(5):427-465.
[4]Rufli T,Mumcuoglu Y.The hair follicle mites Demodex folliculorum and Demodex brevis:biology and medical importance.A review[J].Dermatology, 1981,162(1):1-11.
[5]Nicholls S G,Oakley C L,Tan A,et al.Demodex species in human ocular disease:new clinicopathological aspects[J].Int Ophthalmol, 2017,37(1):303-312.
[6]Elston C A,Elston D M.Demodex mites[J].Clinics in Dermatology, 2014,32(6):739-743.
[7]Bhandari V,Reddy J K.Blepharitis:always remember demodex.[J].Middle East African Journal of Ophthalmology, 2014,21(4):317.
[8]高莹莹,许锻炼,黄丽娟,王蓉.睑缘鳞屑与眼睑蠕形螨寄居关系的临床分析[J].中华眼科杂志, 2009,45(9):834-835.
[9]Kim J T,Lee S H,Chun Y S,et al.Tear cytokines and chemokines in patients with Demodex blepharitis[J].Cytokine, 2011,53(1):94-99.
[10]Keskin,K.R.,et al.,Increased density of Demodex folliculorum mites in pregnancies with gestational diabetes.Med Princ Pract, 2014.23(4):p.369-72.
[11]Randon M,Liang H,El H M,et al.In vivo confocal microscopy as a novel and reliable tool for the diagnosis of Demodex eyelid infestation.[J].Br J Ophthalmol, 2015,99(3):336-341.
[12]梁凌毅,李晶,刘艳.对蠕形螨致睑缘炎诊断中问题的思考[J].中华眼科杂志, 2017,53(9).
[13]Rodríguez A E,Ferrer C,AlióJ L.[Chronic blepharitis and Demodex][J].Archivos De La Sociedad Espanola De Oftalmologia, 2005,80(11):635.
[14]Gao Y Y,Pascuale M A D,Li W,et al.In vitro and in vivo killing of ocular Demodex by tea tree oil.[J].British Journal of Ophthalmology, 2005,89(89):1468-1473.
[15]Halcón L,Milkus K.Staphylococcus aureus and wounds:a review of tea tree oil as a promising antimicrobial.[J].American Journal of Infection Control, 2004,32(7):402-408.
[16]柯兰,杨燕宁,黄林英,王宇静,汪波,李经纬.妥布霉素地塞米松眼膏联合茶树油治疗蠕形螨性睑缘炎的观察[J].中华眼视光学与视觉科学杂志, 2017,19(3):176-181.
[17]Gökçe,C.,et al.,The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus.J Int Med Res,2013.41(5):p.1752-8.
[18]Salem D A,Elshazly A,Nabih N,et al.Evaluation of the efficacy of oral ivermectin in comparison with ivermectin-metronidazole combined therapy in the treatment of ocular and skin lesions of Demodex folliculorum.[J].International Journal of Infectious Diseases Ijid Official Publication of the International Society for Infectious Diseases, 2013,17(5):e343.
[19]Xu Y,Wang L,He J,et al.Prevalence and Control of Diabetes in Chinese Adults[J].Journal of the American Medical Association, 2013,310(9):948-959.
[20]Xu Y,Wang L,He J,et al.Prevalence and control of diabetes in Chinese adults.[J].Jama the Journal of the American Medical Association, 2013,310(9):948-959.
[21]Clifford C W,Fulk G W.Association of Diabetes,Lash Loss,and Staphylococcus aureus with Infestation of Eyelids by Demodex folliculorum(Acari:Demodicidae)[J].Journal of Medical Entomology, 1990,27(4):467-470.
[22]Ünal,E.,A.U.Güvendi and A.Arduç,Hidradenitis Suppurativa,Metabolic Syndrome,and Demodex spp.Infestation.Turkiye Parazitol Derg, 2018.42(2):p.171-174.
[23]Gökçe C,Aycan-KayaÖ,Yula E,et al.The effect of blood glucose regulation on the presence of opportunistic Demodex folliculorum mites in patients with type 2 diabetes mellitus[J].J Int Med Res., 2013,41(5):1752-1758.
[24]Yamashita L S,Cariello A J,Geha N M,et al.Demodex folliculorum on the eyelash follicule of diabetic patients[J].Arquivos Brasileiros De Oftalmologia, 2011,74(6):422-424.
[25]Cengiz Z T,Ozkol H U,Beyhan Y E,et al.Evaluation of some chronical diseases in etiopathogenesis of demodicosis[J].Dermatologica Sinica, 2017.
[26]Yagdiran D O,Aytekin S.Comparison of Demodex folliculorum density in haemodialysis patients with a control group.[J].Journal of the European Academy of Dermatology&Venereology Jeadv, 2007,21(4):480.
[27]Nara T,Katoh N,Inoue K,et al.Eosinophilic folliculitis with a Demodex folliculorum infestation successfully treated with ivermectin in a man infected with human immunodeficiency virus[J].Clinical&Experimental Dermatology, 2009,34(8):e981-e983.
[28]Chang H N.[Chemotaxis of blood monocytes and polymorphonuclear leukocytes from patients with diabetes mellitus][J].Zhonghua Minguo wei sheng wu xue za zhi=Chinese journal of microbiology, 1979,12(4):136-139.
[29]Bagdade J D,Nielson K L,Bulger R J.Reversible abnormalities in phagocytic function in poorly controlled diabetic patients.[J].American Journal of the Medical Sciences, 1972,263(6):451-456.
[30]Sannomiya P,Oliveira M A,Fortes Z B.Aminoguanidine and the prevention of leukocyte dysfunction in diabetes mellitus:a direct vital microscopic study[J].British Journal of Pharmacology, 1997,122(5):894-898.
[31]Moriguchi P,Sannomiya P,Lara P F,et al.Lymphatic system changes in diabetes mellitus:role of insulin and hyperglycemia[J].Diabetes/metabolism Research&Reviews, 2005,21(2):150-157.
[32]Alba-Loureiro T C,Martins E F,Landgraf R G,et al.Role of insulin on PGE 2 generation during LPS-induced lung inflammation in rats[J].Life Sciences, 2006,78(6):578-585.
[33]Huang Y,Yang B,Li W.Defining the normal"core microbiome"of conjunctival microbial communities[J].Clinical Microbiology&Infection the Official Publication of the European Society of Clinical Microbiology&Infectious Diseases, 2016,22(7):643-647.
[34]Martins E N,Alvarenga L S,Höflinglima A L,et al.Aerobic bacterial conjunctival flora in diabetic patients.[J].Cornea, 2004,23(2):136-142.
[35]Fernández-Rubio M E,Rebolledo-Lara L,Martinez-García M,et al.The conjunctival bacterial pattern of diabetics undergoing cataract surgery[J].Eye, 2010,24(5):825.
[36]Thoemmes M S,Fergus D J,Urban J,et al.Ubiquity and diversity of human-associated Demodex mites[J].Plos One, 2014,9(8):e106265.
[37]Nicholls S G,Oakley C L,Tan A,et al.Demodex species in human ocular disease:new clinicopathological aspects[J].Int Ophthalmol, 2017,37(1):303-312.
[38]Wolf R,Ophir J,Avigad J,et al.The hair follicle mites(Demodex spp.).Could they be vectors of pathogenic microorganisms?[J].Acta dermato-venereologica, 1988,68(6):535-537.
[39]Stephenson J,Fuller J H.Microvascular and acute complications in IDDM patients:the EURODIAB IDDM Complications Study[J].Diabetologia, 1994,37(3):278-285.
[40]Pambianco G,Costacou T,Ellis D,et al.The 30-year natural history of type 1 diabetes complications:the Pittsburgh Epidemiology of Diabetes Complications Study experience[J].Diabetes, 2006,55(5):1463.
[41]Sperling L C.Hair anatomy for the clinician[J].Journal of the American Academy of Dermatology, 1991,25(1 Pt 1):1-17.
[42]Piérard G E,Piérard-Franchimont C,Marks R,et al.EEMCO guidance for the assessment of hair shedding and alopecia[J].Skin Pharmacol Physiol, 2004,17(2):98-110.
[43]Plikus M V,Spyk E N V,Pham K,et al.The circadian clock in skin:implications for adult stem cells,tissue regeneration,cancer,aging,and immunity[J].Journal of Biological Rhythms, 2015,30(3):163.
[44]Hayashi S,Miyamoto I,Takeda K.Measurement of human hair growth by optical microscopy and image analysis.[J].British Journal of Dermatology, 1991,125(2):123.
[45]Andl T,Ahn K,Kairo A,et al.Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development[J].Development, 2004,131(10):2257-2268.
[46]Paus R,Christoph T,Müllerröver S.Immunology of the hair follicle:a short journey into terra incognita.[J].J Investig Dermatol Symp Proc, 1999,4(3):226-234.
[47]Cakmak S,Gül U,Gönül M,et al.Statin therapy and diabetic skin.[J].Advances in Therapy, 2008,25(1):17-22.
Copyright © 2020 黄 畅, 李振豪, 李思琪, 符 敏, 李海量, 易果果
Publishing time:2020-12-29
This work is licensed under a Creative Commons Attribution 4.0 International License
Email
Location