Preparation of Antibiotics-containing Electrospinning Chitosan/Gelatin Nanofibers
Salim Salman （ Department of Chemical Engineering, College of Engineering, University of Baghdad, 47024, Baghdad, Iraq. ）
Saeed Yaseen （ Department of Chemical Engineering, College of Engineering, University of Baghdad, 47024, Baghdad, Iraq. ）
https://doi.org/10.37155/2717-526X-0401-4Abstract
The electrospun nanofibers-based systems have opened new windows on drug delivery systems. Antibiotic treatment and drug resistance in infectious disease management have introduced some potential applications of using electrospun nanofibers. In this respect, chitosan/gelatin nanofibers can be considered a reliable source for drug delivery. This study aimed to synthesize antibiotics-containing electrospinning chitosan/gelatin nanofibers. To this end, electrospinning was performed using different concentrations of chitosan and gelatin, followed by adding ceftriaxone to the corresponding solutions. Afterward, nanofibers were crosslinked through ceftriaxone loading. The nanofiber was characterized in terms of its morphology via scanning electron microscopy (SEM) analyses. In addition, spectrophotometrical analysis was performed to examine the amount of released ceftriaxone at 280 nm wavelength. Eventually, SPSS version 21 was used to perform statistical analyses. Based on the obtained results, the mean Gelatin diameters before and after crosslinking were 154.5±286 and 162.3±27, respectively; the mean Chitosan/gelatin (95:5) diameters before and after crosslinking were 192±25 and 208±11.6 respectively. Finally, the mean Chitosan/gelatin (80:20) diameters before and after crosslinking were 188.2±34.7 and 212.1±54.8, respectively. Overall, the obtained results indicate that the fiber diameters increase after crosslinking and by adding chitosan. This increase can be attributed to polymer chain entanglement in the gelatin chain reaction with glutaraldehyde’s aldehyde group. In addition, despite the short drug release time (i.e., 240 min). In general, chitosan lowered the drug release rate in comparison to gelatin nanofibrous. In conclusion, the fiber diameters rise with adding chitosan, followed by its glutaraldehyde crosslinking. The nanofibers showed a considerably higher drug release compared to polymeric films. Nevertheless, gelatin nanofibers such as chitosan decline the ceftriaxone release rate compared to gelatin nanofibers. Furthermore, prolonging the buffer solution immersion time enhances the drug release percentage.
Keywords
Electrospinning; Chitosan/Gelatin nanofibers; Antibiotics; Ceftriaxone; Drug deliveryFull Text
PDFReferences
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5. Ziyadi H, Baghali M, Bagherianfar M, Mehrali F, Faridi-Majidi R. An investigation of factors affecting the electrospinning of poly (vinyl alcohol)/kefiran composite nanofibers. Advanced Composites and Hybrid Materials. 2021 Sep;4(3):768-79.
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8. Su S, Bedir T, Kalkandelen C, Başar AO, Şaşmazel HT, Ustundag CB, Sengor M, Gunduz O. Coaxial and emulsion electrospinning of extracted hyaluronic acid and keratin based nanofibers for wound healing applications. European Polymer Journal. 2021 Jan 5;142:110158.
9. Haider S, Al‐Masry WA, Bukhari N, Javid M. Preparation of the chitosan containing nanofibers by electrospinning chitosan–gelatin complexes. Polymer Engineering & Science. 2010 Sep;50(9):1887-93.
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11. Angel N, Li S, Yan F, Kong L. Recent advances in electrospinning of nanofibers from bio-based carbohydrate polymers and their applications. Trends in Food Science & Technology. 2022 Jan 5.
12. Rahman MM, Pervez S, Nesa B, Khan MA. Preparation and characterization of porous scaffold composite films by blending chitosan and gelatin solutions for skin tissue engineering. Polymer international. 2013 Jan;62(1):79-86.
13. Moghadas B, Dashtimoghadam E, Mirzadeh H, Seidi F, Hasani-Sadrabadi MM. Novel chitosan-based nanobiohybrid membranes for wound dressing applications. Rsc Advances. 2016;6(10):7701-11.
14. Pezeshki‐Modaress M, Zandi M, Mirzadeh H. Fabrication of gelatin/chitosan nanofibrous scaffold: process optimization and empirical modeling. Polymer International. 2015 Apr;64(4):571-80.
15. Blackstone BN, Drexler JW, Powell HM. Tunable engineered skin mechanics via coaxial electrospun fiber core diameter. Tissue Engineering Part A. 2014 Oct 1;20(19-20):2746-55.
16. Azimi R, Abdollahi A, Roghani-Mamaqani H, Salami-Kalajahi M. Dual-mode security anticounterfeiting and encoding by electrospinning of highly photoluminescent spiropyran nanofibers. Journal of Materials Chemistry C. 2021;9(30):9571-83.
17. Xu Y, Ndayikengurukiye J, Akono AT, Guo P. Fabrication of fiber-reinforced polymer ceramic composites by wet electrospinning. Manufacturing Letters. 2022 Jan 1;31:91-5.
18. Pillay V, Dott C, Choonara YE, Tyagi C, Tomar L, Kumar P, du Toit LC, Ndesendo VM. A review of the effect of processing variables on the fabrication of electrospun nanofibers for drug delivery applications. Journal of Nanomaterials. 2013 Oct;2013.
19. Maliszewska I, Czapka T. Electrospun Polymer Nanofibers with Antimicrobial Activity. Polymers. 2022 Apr 20;14(9):1661.
20. Son YJ, Kim WJ, Yoo HS. Therapeutic applications of electrospun nanofibers for drug delivery systems. Archives of pharmacal research. 2014 Jan;37(1):69-78.
21. Ignatious F, Sun L, Lee CP, Baldoni J. Electrospun nanofibers in oral drug delivery. Pharmaceutical research. 2010 Apr;27(4):576-88.
22. Kajdič S, Planinšek O, Gašperlin M, Kocbek P. Electrospun nanofibers for customized drug-delivery systems. Journal of Drug Delivery Science and Technology. 2019 Jun 1;51:672-81.
23. Cleeton C, Keirouz A, Chen X, Radacsi N. Electrospun nanofibers for drug delivery and biosensing. ACS Biomaterials Science & Engineering. 2019 Aug 12;5(9):4183-205.
24. Torres-Martínez EJ, Cornejo Bravo JM, Serrano Medina A, Pérez González GL, Villarreal Gómez LJ. A summary of electrospun nanofibers as drug delivery system: Drugs loaded and biopolymers used as matrices. Current Drug Delivery. 2018 Dec 1;15(10):1360-74.
25. Williams GR, Chatterton NP, Nazir T, Yu DG, Zhu LM, Branford-White CJ. Electrospun nanofibers in drug delivery: recent developments and perspectives. Therapeutic delivery. 2012 Apr;3(4):515-33.
26. Balusamy B, Celebioglu A, Senthamizhan A, Uyar T. Progress in the design and development of “fast-dissolving” electrospun nanofibers based drug delivery systems-A systematic review. Journal of Controlled Release. 2020 Oct 10;326:482-509.
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28. Zhao K, Kang SX, Yang YY, Yu DG. Electrospun functional nanofiber membrane for antibiotic removal in water. Polymers. 2021 Jan 11;13(2):226.
29. Maleki Dizaj S, Sharifi S, Jahangiri A. Electrospun nanofibers as versatile platform in antimicrobial delivery: Current state and perspectives. Pharmaceutical Development and Technology. 2019 Nov 26;24(10):1187-99.
30. Brimo N, Serdaroğlu DÇ, Uysal B. Comparing Antibiotic Pastes with Electrospun Nanofibers as Modern Drug Delivery Systems for Regenerative Endodontics. Current Drug Delivery. 2021 Dec 16.
31. Torres-Martínez EJ, Cornejo Bravo JM, Serrano Medina A, Pérez González GL, Villarreal Gómez LJ. A summary of electrospun nanofibers as drug delivery system: Drugs loaded and biopolymers used as matrices. Current Drug Delivery. 2018 Dec 1;15(10):1360-74.
32. Topuz F, Kilic ME, Durgun E, Szekely G. Fast-dissolving antibacterial nanofibers of cyclodextrin/antibiotic inclusion complexes for oral drug delivery. Journal of Colloid and Interface Science. 2021 Mar 1;585:184-94.
33. Wang M, Roy AK, Webster TJ. Development of chitosan/poly (vinyl alcohol) electrospun nanofibers for infection related wound healing. Frontiers in physiology. 2017 Jan 11;7:683.
34. Duceac LD, Calin G, Eva L, Marcu C, Bogdan Goroftei ER, Dabija MG, Mitrea G, Luca AC, Hanganu E, Gutu C, Stafie L. Third-generation cephalosporin-loaded chitosan used to limit microorganisms resistance. Materials. 2020 Oct 27;13(21):4792.
35. Alkekhia D, LaRose C, Shukla A. β-Lactamase-Responsive Hydrogel Drug Delivery Platform for Bacteria-Triggered Cargo Release. ACS Applied Materials & Interfaces. 2022 Jun 8.
36. Naveen V, Siddiq A, Chandana G. A study on drug utilization pattern of cephalosporins in general medicine and surgical inpatient department. Int J Curr Pharm Res. 2018;10(3):33-6.
37. Kanwal T, Kawish M, Maharjan R, Ghaffar I, Ali HS, Imran M, Perveen S, Saifullah S, Simjee SU, Shah MR. Design and development of permeation enhancer containing self-nanoemulsifying drug delivery system (SNEDDS) for ceftriaxone sodium improved oral pharmacokinetics. Journal of Molecular liquids. 2019 Sep 1;289:111098.
38. Murueva AV, Shershneva AM, Abanina KV, Prudnikova SV, Shishatskaya EI. Development and characterization of ceftriaxone-loaded P3HB-based microparticles for drug delivery. Drying Technology. 2019 Jul 4;37(9):1131-42.
39. Hussain K, Aslam Z, Ullah S, Shah MR. Synthesis of pH responsive, photocrosslinked gelatin-based hydrogel system for control release of ceftriaxone. Chemistry and Physics of Lipids. 2021 Aug 1;238:105101.
40. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery. 2021 Feb;20(2):101-24.
41. Li C, Wang J, Wang Y, Gao H, Wei G, Huang Y, Yu H, Gan Y, Wang Y, Mei L, Chen H. Recent progress in drug delivery. Acta pharmaceutica sinica B. 2019 Nov 1;9(6):1145-62.
42. Zhao Z, Ukidve A, Kim J, Mitragotri S. Targeting strategies for tissue-specific drug delivery. Cell. 2020 Apr 2;181(1):151-67.
43. Topuz F, Kilic ME, Durgun E, Szekely G. Fast-dissolving antibacterial nanofibers of cyclodextrin/antibiotic inclusion complexes for oral drug delivery. Journal of Colloid and Interface Science. 2021 Mar 1;585:184-94.
44. Visscher LE, Dang HP, Knackstedt MA, Hutmacher DW, Tran PA. 3D printed Polycaprolactone scaffolds with dual macro-microporosity for applications in local delivery of antibiotics. Materials science and engineering: C. 2018 Jun 1;87:78-89.
45. He FL, Deng X, Zhou YQ, Zhang TD, Liu YL, Ye YJ, Yin DC. Controlled release of antibiotics from poly‐ε‐caprolactone/polyethylene glycol wound dressing fabricated by direct‐writing melt electrospinning. Polymers for Advanced Technologies. 2019 Feb;30(2):425-34.
46. Shahriar SS, Mondal J, Hasan MN, Revuri V, Lee DY, Lee YK. Electrospinning nanofibers for therapeutics delivery. Nanomaterials. 2019 Apr 3;9(4):532.
47. Abdoli M, Sadrjavadi K, Arkan E, Zangeneh MM, Moradi S, Zangeneh A, Khaledian S. Polyvinyl alcohol/Gum tragacanth/graphene oxide composite nanofiber for antibiotic delivery. Journal of Drug Delivery Science and Technology. 2020 Dec 1;60:102044.
48. Nematpour N, Farhadian N, Ebrahimi KS, Arkan E, Seyedi F, Khaledian S, Shahlaei M, Moradi S. Sustained release nanofibrous composite patch for transdermal antibiotic delivery. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2020 Feb 5;586:124267.
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Copyright © 2022 Saeed Yaseen, Salim Salman
Publishing time:2022-07-08
This work is licensed under a Creative Commons Attribution 4.0 International License
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