生物活性递送系统的研究前沿与临床转化应用进展

张 量 ( 中国药科大学 药学院 )

王 婷 ( 中国药科大学 药学院 )

陈逸秋 ( 中国药科大学 药学院 )

唐国玲 ( 中国药科大学 药学院 )

熊 慧* ( 中国药科大学 药学院 )

https://doi.org/10.37155/2717-5650-0606-28

Abstract

生物活性递送系统,尤其是基于活细胞、活细菌、外泌体和细菌外膜囊泡的递药技术,近年来在药物递 送领域取得了显著进展。这些生物载体凭借其天然的生物相容性、靶向性和免疫逃逸能力,为药物的精准递送提供了 新的途径。本文综述了这些生物活性递药系统的研究进展,重点探讨它们在临床前和临床研究中的应用效果、面临的 挑战以及未来的转化潜力,为进一步推动这些技术的临床应用提供了深入分析和展望。

Keywords

生物活性载体;药物递送;临床研究

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References

[1]CHAVDA V P, PANDYA A, KUMAR L, et al.
Exosome nanovesicles: A potential carrier for therapeutic
delivery[J]. Nano Today, 2023, 49: 101771.
[2]KANG Y, XU C, MENG L, et al. Exosomefunctionalized magnesium-organic framework-based scaffolds
with osteogenic, angiogenic and anti-inflammatory properties
for accelerated bone regeneration[J]. Bioactive Materials,
2022, 18: 26-41.
[3]QIN J, YANG T, LI J, et al. Bacterial outer membrane
vesicle-templated biomimetic nanoparticles for synergistic
photothermo-immunotherapy[J]. Nano Today, 2022, 46:
101591.
[4]SUN Y, MA Y Y, SHANGGUAN S, et al. Metal ionsanchored bacterial outer membrane vesicles for enhanced
ferroptosis induction and immune stimulation in targeted
antitumor therapy[J]. Journal of Nanobiotechnology, 2024,
22(1): 474.
[5]ZHANG E, PHAN P, ALGARNI H A, et al. Red
Blood Cell Inspired Strategies for Drug Delivery: Emerging
Concepts and New Advances[J]. Pharmaceutical Research,
2022, 39(11): 2673-2698.
[6]KWON Y M, CHUNG H S, MOON C, et al.
L-Asparaginase encapsulated intact erythrocytes for treatment
of acute lymphoblastic leukemia (ALL)[J]. Journal of
Controlled Release, 2009, 139(3): 182-189.
[7]HAN X, LI H, ZHOU D, et al. Local and Targeted
Delivery of Immune Checkpoint Blockade Therapeutics[J].
Accounts of Chemical Research, 2020, 53(11): 2521-2533.[8]LI S, LI L, LIN X, et al. Targeted Inhibition of Tumor
Inflammation and Tumor-Platelet Crosstalk by NanoparticleMediated Drug Delivery Mitigates Cancer Metastasis[J]. ACS
Nano, 2022, 16(1): 50-67.
[9]LI Z, WANG Y, DING Y, et al. Cell‐Based Delivery
Systems: Emerging Carriers for Immunotherapy[J]. Advanced
Functional Materials, 2021, 31(23): 2100088.
[10]ZHENG J, QI R, DAI C, et al. Enzyme Catalysis
Biomotor Engineering of Neutrophils for Nanodrug Delivery
and Cell-Based Thrombolytic Therapy[J]. ACS Nano, 2022,
16(2): 2330-2344.
[11]ZHANG T, HUANG T, SU Y, et al. Mesenchymal
Stem Cells‐Based Targeting Delivery System: Therapeutic
Promises and Immunomodulation against Tumor[J]. Advanced
Therapeutics, 2021, 4(8): 2100030.
[12]TAKAYAMA Y, KUSAMORI K, TSUKIMORI C,
et al. Anticancer drug-loaded mesenchymal stem cells for
targeted cancer therapy[J]. Journal of Controlled Release,
2021, 329: 1090-1101.
[13]WU F, LIU J. Decorated bacteria and the application
in drug delivery[J]. Advanced Drug Delivery Reviews, 2022,
188: 114443.
[14]XIAO S, SHI H, ZHANG Y, et al. Bacteria-driven
hypoxia targeting delivery of chemotherapeutic drug proving
outcome of breast cancer[J]. Journal of Nanobiotechnology,
2022, 20(1): 178.

Copyright © 2025 张 量,王 婷,陈逸秋,唐国玲,熊 慧* Creative Commons License Publishing time:2025-06-30
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