导电聚合物微针的制备与应用
褚 忠 （ 上海应用技术大学机械工程学院 ）
康 辉 （ 上海应用技术大学机械工程学院 ）
https://doi.org/10.37155/2717-5197-0608-66Abstract
微针是一种由微型针尖阵列整齐排列在基底上组成的装置。由于其尺寸微小，可以轻易的穿过皮肤角质 层而不产生疼痛感，目前已经广泛的应用于经皮给药。本文介绍了一种导电聚合物微针的制备方法，以可降解塑料和 导电填充材料制备3D打印导电丝材，利用FDM 3D打印将丝材制备成导电膜，通过模具浇注和加入导电膜的方法制备 导电微针，并对导电聚合物微针力学性能和导电性能检测，其结果满足使用需求。所制备的导电聚合物微针通过与传 感器相结合，将药物加载在电响应性载体中，可以有效的促进药物释放以及药物的给药情况检测。
Keywords
微针；导电聚合物；经皮给药Full Text
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biomedical nanotechnology, 2017, 13(12):1581-1597.
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Integrated Ultrasonic Microneedle Array for Rapid Transdermal
Drug Delivery.[J].Molecular pharmaceutics,2022,19(9):
[3]Makvandi P, Jamaledin R, Chen G, et al. Stimuli_x0002_responsive transdermal microneedle patches[J]. Materials
Today, 2021, 47: 206-222.
[4]Svirskis D, Travas-Sejdic J, Rodgers A, et al.
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intrinsically conducting polymers[J]. Journal of Controlled
Release, 2010, 146(1): 6-15.
[5]M. Ottenbrite R ,Kinam Park ,Teruo Okano
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New York, 2010, 319.
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of chitosan-porous carbon nanocomposites: Stimuli (pH
and electric field)-initiated drug delivery and toxicological
studies[J]. Journal of Biomedical Materials Research Part A,
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delivery of anesthetic agents to bone tissues using conductive
microneedles enhanced iontophoresis for painless dental
anesthesia[J]. Advanced Functional Materials, 2021, 31(47):
2105686.
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composites characterization and its applications: A review[J].
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Copyright © 2024 褚 忠,康 辉
Publishing time:2024-04-30
This work is licensed under a Creative Commons Attribution 4.0 International License
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