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Vol 3 No 2 (2021)

  • Alpha-fetoprotein Promotes the Malignant Phenotype of Hepatocellular Carcinoma Cells: The Drugs Resistance Origination

    Xue Shan, Minni Zhang, Haifeng Lin, Mingyue Zhu, Mengsen Li

    Hepatocellular carcinoma (HCC) has a high increase, recurrence and mortality rate, but the signs of pathogenesis are not clear. At the time of diagnosis, most patients were advanced stage and missed the optimal period of surgical resection. Pharmacotherapy is the primary choice in this period, but the efficacy of anticancer drugs is poor and the patient survival rate is low. Drugs resistance is the primary cause of the poor efficacy of anticancer drugs. HCC cells have innate drugs resistance and acquired drugs resistance, and understanding the drugs resistance mechanism of HCC cells has an important help in the treatment of HCC. Alpha fetoprotein (AFP) is a tumor-associated protein, about 70% high expression of AFP in HCC patients, and AFP has a trait to induce malignant phenotype, stimulate cancer cells with a highly aggressive, antiapoptotic, proliferated phenotype, etc. AFP can also promote HCC drugs resistance through regulating the transduction of signaling pathways and ultimately lead to drugs resistance. This review analyze AFP influences the origination of cancer stem cells, promotes malignant phenotype of cancer cells, and the mechanism that promote HCC cells drugs resistance.

  • Gene Expression Profiles Reveal the Potential Link between Parkinson’s Disease and Gastric Cancer

    Lei Zhang, Zhiming Ma, Suyan Tian

    Introduction: Gastric cancer (GC) is a cancer that develops from the lining of the stomach. Parkinson’s disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. Even though these two diseases seem to be distinct from each other, increasing evidences suggest that they might be linked. The objective of this study is two-fold. One is to explore if these two diseases are associated from the perspective of gene expression profiles. The other is to examine if race plays an interaction role on the association between these two diseases. Methods: Moderated t-tests or moderated paired t-tests were carried out to identify differentially expressed genes (DEGs) between the diseased people and the normal controls. Upon the overlapped DEGs between PD and GC, biological relevance was investigated using GeneCards database. Results and Discussion: Our analysis results showed that PD and GC are related to each other. Furthermore, our analysis suggest that these two diseases may be associated negatively with each other, and race is unlikely to play an interaction role on this association. Conclusions: This study may serve as a pilot study, and it will stimulate more work to investigate the link between distinct diseases using big omics data.

  • Clinical Analysis of Areola Small Incision Surgery for Benign Breast Tumors

    Stephan Ohlinger

    Objective: To explore the clinical treatment analysis of areola small incision surgery for benign breast tumors. Methods: 100 patients with benign breast tumors were selected as the test subjects, divided into 2 groups by simple randomization method, 50 cases were the control group, 50 cases were the experimental group, and the admission time was from January 2020 to June 2021; the control group Traditional open surgical treatment was given, and the experimental group was treated with areola small incision surgery. The operation status, complications and treatment satisfaction of the two groups were compared. Results: The operation time and hospital stay of the experimental group were shorter than those of the control group, the amount of intraoperative blood loss was less than that of the control group, and the length of operation was shorter than that of the control group (P<0.05); the total incidence of complications in the experimental group was lower than that of the control group ( P<0.05); the total satisfaction of clinical treatment of the experimental group was higher than that of the control group (P<0.05). Conclusion: The clinical treatment of benign breast tumors with areola small incision surgery is significant.

  • The Effect of Balanced Analgesia with Sufentanil and Flurbiprofen Axetil in Patients with Cervical Cancer after Open Surgery

    Tianxin Dong

    Objective: To study the effect of balanced analgesia with sufentanil and flurbiprefen axetil in patients with cervical cancer after open surgery. Methods: 92 patients with cervical cancer treated in our hospital from October 2018 to December 2020 were selected. All patients were treated with open surgery for cervical cancer. According to the odd even grouping method, the patients were divided into observation group and control group, with 46 cases in each group. Sufentanil was used for postoperative analgesia in the control group, and sufentanil combined with flurbiprofen axetil was used for postoperative analgesia in the observation group. Serum prostaglandin E2 (PGE2), β Endorphins(β- EP), cortisol (COR), 5-hydroxytryptamine (5-HT), VAS score at different time points after operation and the number of presses of patient-controlled intravenous analgesia pump (PCIA) were compared. Results: Before operation, serum PGE2, β- Comparison of EP, Cor and 5-HT levels were compareed, P > 0.05; 24 hours after operation, the above indexes in the observation group were significantly lower than those in the control group (P < 0.05); The VAS scores of the observation group at different time points were lower than those of the control group (P < 0.05); The incidence of adverse reactions in the observation group was 6.52%, lower than 23.91% in the control group (P < 0.05). Conclusion: In the postoperative analgesia of patients with cervical cancer after open surgery, the application of sufentanil combined with flurbiprofen axetil balanced analgesia can not only reduce the secretion of related factors, but also improve the analgesic effect with less adverse reactions, which is worthy of clinical reference.

  • Correlation between Hp Infection with Clinicopathological Features, Tumor Markers, Oncogene Expression in Patients with Gastric Cancer

    Jonathan Yeoh

    Objective: To study the correlation between Helicobacter pylori (Hp) infection with clinicopathological features, tumor markers, oncogene expression in patients with gastric cancer. Methods: 180 gastric cancer patients who underwent surgical resection in our hospital from February 2019 to March 2021 were selected. The clinicopathological characteristics of the patients were collected. The content of tumor markers was measured after serum collection. The HP infection and oncogene expression were measured after the collection of gastric cancer lesions and adjacent lesions. Results: The HP infection rate in 180 cases of gastric cancer was 56.67%; the HP infection rate in TNM stage III and TNM stage II was significantly higher than that in TNM stage I and the HP infection rate in TNM stage III was significantly higher than that in TNM stage II; the HP infection rate in poorly differentiated gastric cancer was significantly higher than that in moderately differentiated gastric cancer; the HP infection rate in gastric cancer tissues with depth of T3+T4 was significantly higher than that of T1+T2. The levels of serum CEA, CA19-9 and VEGF in patients with HP-positive gastric cancer tissues were significantly higher than those in patients with HP-negative gastric cancer tissues, the level of PGR was significantly lower than those in patients with HP-negative gastric cancer tissues;  the mRNA expression of c-myc, c-Met and Bmi-1 in HP-positive gastric cancer tissues were significantly higher than those in HP-negative gastric cancer tissues; the mRNA expression of GKN1 and p16 were significantly lower than those in HP-negative gastric cancer tissues. Conclusion: Hp infection in patients with gastric cancer correlates with the changes of clinicopathological features, the increase of tumor markers and abnormal expression of oncogene.