Sustainability in Pharmaceutical Formulation and Processing: Case Studies on Eco-Friendly Micronisation and Nanonisation Approaches This Article Belongs To The Special Issue: Sustainable Process Engineering: Collaborations between Industry and Academia

Hien V. Nguyen, Thuy Thi-Nhu Huynh, Linh Nguyen-Ngoc Pham, Tung Minh Ta

The pharmaceutical industry faces growing pressure to adopt sustainable practices throughout the entire product lifecycle, encompassing the design and synthesis of active pharmaceutical ingredients (APIs), manufacturing, distribution, usage, and disposal of pharmaceutical products. Addressing these challenges demands innovative strategies that balance environmental responsibility with economic and operational feasibility. This paper examines key approaches to achieving sustainability in pharmaceutical formulation and processing, including the use of biodegradable materials, minimizing organic solvent consumption, and implementing energy-efficient continuous manufacturing technologies. Through detailed case studies from our research group, we demonstrate the successful application of these principles to develop eco-friendly formulations and optimize manufacturing processes for pharmaceutical micronisation and nanonisation. This work aims to guide further advancements in sustainable pharmaceutical development.