自身免疫性疾病中的铁蛋白抗体及可能的产生机制
郝山凤 ( 天津医科大学总医院 )
Abstract
多项研究发现多种自身免疫性疾病中存在铁蛋白抗体,并且推测抗体的产生可能是由于某种微生物的铁蛋白与体内的铁蛋白产生了交叉抗原反应。本文就自身免疫性疾病中发现铁蛋白抗体的研究以及微生物铁蛋白对宿主免疫的影响两方面进行综述。
Keywords
铁蛋白; 自身抗原; 微生物铁蛋白; 宿主免疫Full Text
PDFReferences
[1]Kernan KF, Carcillo JA. Hyperferritinemia and inflammation. International immunology. 2017;29(9):401-9. doi:10.1093/intimm/dxx031.
[2]Mewar D, Moore DJ, Young-Min S, Bertolaccini ML, Khamashta MA, Watson PF etal. Antiferritin antibodies discovered by phage display expression cloning are associated with radiographic damage in rheumatoid arthritis. Arthritis and rheumatism. 2005;52(12):3868-72. doi:10.1002/art.21483.
[3]Baerlecken NT, Linnemann A, Gross WL, Moosig F, Vazquez-Rodriguez TR, Gonzalez-Gay MA etal. Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica. Ann Rheum Dis. 2012;71(6):943-7. doi:10.1136/annrheumdis-2011-200413.
[4]Große K, Schmidt RE, Witte T, Baerlecken NT. Epitope mapping of antibodies against ferritin heavy chain in giant cell arteritis and polymyalgia rheumatica. Scandinavian Journal of Rheumatology. 2013;42(3):215-9.
[5]Grosse K, Witte T, Moosig F, Hoyer BF, Lansche C, Schmidt RE et al. Association of ferritin antibodies with Takayasu arteritis. Clin Rheumatol. 2014;33(10):1523-6. doi:10.1007/s10067-014-2764-2.
[6]Liu H, Fu R, Wang Y, Liu H, Li L, Wang H et al. Detection and analysis of autoantigens targeted by autoantibodies in immunorelated pancytopenia. Clinical & developmental immunology. 2013;2013:297678. doi:10.1155/2013/297678.
[7]Hao S, Fu R, Wang H, Shao Z. Screening novel autoantigens targeted by serum IgG autoantibodies in immunorelated pancytopenia by SEREX. International journal of hematology. 2017;106(5).
[8]Hao S, Zhang Y, Hua L et al. Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immunerelated pancytopenia. Molecular Medicine Reports, 2020, 22(3).
[9]Moreira AC, Mesquita G, Gomes MS. Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions. Microorganisms. 2020;8(4). doi:10.3390/microorganisms8040589.
[10]Chareyre S, Mandin P. Bacterial Iron Homeostasis Regulation by sRNAs. Microbiology spectrum. 2018;6(2). doi:10.1128/microbiolspec.RWR-0010-2017.
[11]Almiron M, Link AJ, Furlong D, Kolter R. A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli. Genes & development. 1992;6(12B):2646-54. doi:10.1101/gad.6.12b.2646.
[12]Minato T, Teramoto T, Kakuta Y, Ogo S, Yoon KS. Biochemical and structural characterization of a thermostable Dps protein with His-type ferroxidase centers and outer metal-binding sites. FEBS open bio. 2020. doi:10.1002/2211-5463.12837.
[13]Mohamed W, Darji A, Domann E, Chiancone E, Chakraborty T. The ferritin-like protein Frm is a target for the humoral immune response to Listeria monocytogenes and is required for efficient bacterial survival. Molecular genetics and genomics : MGG. 2006;275(4):344-53. doi:10.1007/s00438-005-0090-8.
[14]Mohamed W, Sethi S, Darji A, Mraheil MA, Hain T, Chakraborty T. Antibody targeting the ferritin-like protein controls Listeria infection. Infection and Immunity. 2010;78(7):3306-14. doi:10.1128/IAI.00210-10.
[15]Choi S, Choi HG, Shin KW, Back YW, Park HS, Lee JH et al. Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response. Journal of immunology research. 2018;2018:3525302. doi:10.1155/2018/3525302.
[16]Wang Y, Wang Q, Lv S, Zhang S. Different protein of Echinococcus granulosus stimulates dendritic induced immune response. Parasitology. 2015;142(7):879-89. doi:10.1017/S0031182014002005.
[17]Soleimani N, Mohabati Mobarez A, Tavakoli-Yaraki M, Farhangi B. Evaluation of nitric oxide production and proliferation activity of recombinant Bacterioferritin of Helicobacter pylori on macrophages. Microbial pathogenesis. 2016;100:149-53. doi:10.1016/j.micpath.2016.07.008.
[2]Mewar D, Moore DJ, Young-Min S, Bertolaccini ML, Khamashta MA, Watson PF etal. Antiferritin antibodies discovered by phage display expression cloning are associated with radiographic damage in rheumatoid arthritis. Arthritis and rheumatism. 2005;52(12):3868-72. doi:10.1002/art.21483.
[3]Baerlecken NT, Linnemann A, Gross WL, Moosig F, Vazquez-Rodriguez TR, Gonzalez-Gay MA etal. Association of ferritin autoantibodies with giant cell arteritis/polymyalgia rheumatica. Ann Rheum Dis. 2012;71(6):943-7. doi:10.1136/annrheumdis-2011-200413.
[4]Große K, Schmidt RE, Witte T, Baerlecken NT. Epitope mapping of antibodies against ferritin heavy chain in giant cell arteritis and polymyalgia rheumatica. Scandinavian Journal of Rheumatology. 2013;42(3):215-9.
[5]Grosse K, Witte T, Moosig F, Hoyer BF, Lansche C, Schmidt RE et al. Association of ferritin antibodies with Takayasu arteritis. Clin Rheumatol. 2014;33(10):1523-6. doi:10.1007/s10067-014-2764-2.
[6]Liu H, Fu R, Wang Y, Liu H, Li L, Wang H et al. Detection and analysis of autoantigens targeted by autoantibodies in immunorelated pancytopenia. Clinical & developmental immunology. 2013;2013:297678. doi:10.1155/2013/297678.
[7]Hao S, Fu R, Wang H, Shao Z. Screening novel autoantigens targeted by serum IgG autoantibodies in immunorelated pancytopenia by SEREX. International journal of hematology. 2017;106(5).
[8]Hao S, Zhang Y, Hua L et al. Antibodies specific to ferritin light chain polypeptide are frequently detected in patients with immunerelated pancytopenia. Molecular Medicine Reports, 2020, 22(3).
[9]Moreira AC, Mesquita G, Gomes MS. Ferritin: An Inflammatory Player Keeping Iron at the Core of Pathogen-Host Interactions. Microorganisms. 2020;8(4). doi:10.3390/microorganisms8040589.
[10]Chareyre S, Mandin P. Bacterial Iron Homeostasis Regulation by sRNAs. Microbiology spectrum. 2018;6(2). doi:10.1128/microbiolspec.RWR-0010-2017.
[11]Almiron M, Link AJ, Furlong D, Kolter R. A novel DNA-binding protein with regulatory and protective roles in starved Escherichia coli. Genes & development. 1992;6(12B):2646-54. doi:10.1101/gad.6.12b.2646.
[12]Minato T, Teramoto T, Kakuta Y, Ogo S, Yoon KS. Biochemical and structural characterization of a thermostable Dps protein with His-type ferroxidase centers and outer metal-binding sites. FEBS open bio. 2020. doi:10.1002/2211-5463.12837.
[13]Mohamed W, Darji A, Domann E, Chiancone E, Chakraborty T. The ferritin-like protein Frm is a target for the humoral immune response to Listeria monocytogenes and is required for efficient bacterial survival. Molecular genetics and genomics : MGG. 2006;275(4):344-53. doi:10.1007/s00438-005-0090-8.
[14]Mohamed W, Sethi S, Darji A, Mraheil MA, Hain T, Chakraborty T. Antibody targeting the ferritin-like protein controls Listeria infection. Infection and Immunity. 2010;78(7):3306-14. doi:10.1128/IAI.00210-10.
[15]Choi S, Choi HG, Shin KW, Back YW, Park HS, Lee JH et al. Mycobacterium tuberculosis Protein Rv3841 Activates Dendritic Cells and Contributes to a T Helper 1 Immune Response. Journal of immunology research. 2018;2018:3525302. doi:10.1155/2018/3525302.
[16]Wang Y, Wang Q, Lv S, Zhang S. Different protein of Echinococcus granulosus stimulates dendritic induced immune response. Parasitology. 2015;142(7):879-89. doi:10.1017/S0031182014002005.
[17]Soleimani N, Mohabati Mobarez A, Tavakoli-Yaraki M, Farhangi B. Evaluation of nitric oxide production and proliferation activity of recombinant Bacterioferritin of Helicobacter pylori on macrophages. Microbial pathogenesis. 2016;100:149-53. doi:10.1016/j.micpath.2016.07.008.
Copyright © 2021 郝山凤 Publishing time:2021-03-30
This work is licensed under a Creative Commons Attribution 4.0 International License