结直肠癌bcl-2和β-catenin的表达及临床意义
徐 晨 （ 齐齐哈尔医学院病理学院 ）
于秀文 （ 齐齐哈尔医学院病理学院 ）
https://doi.org/10.37155/2717-5669-0401-15Abstract
目的： 检测结直肠腺癌组织及癌旁正常组织bcl-2、 β-catenin蛋白表达，探讨bcl-2、 β-catenin与患者的年 龄、性别、肿瘤部位、分化程度、与、浸润深度、淋巴结转移及TNM分期等临床病理参数的关系。 方法： 原发性结直 肠腺癌及对应的癌旁正常组织各62例用免疫组织化学方法检测bcl-2、 β-catenin蛋白表达情况。结果 结直肠癌组织bcl- 2、 β-catenin蛋白表达高于远切端正常黏膜， bcl-2与浸润深度、淋巴结转移及TNM分期有关（ P < 0.05）； β-catenin与 肿瘤的分化程度、淋巴结转移及TNM分期有关（ P < 0.05）。 结论： 结直肠腺癌组织bcl-2和β-catenin在结直肠癌组织 中高表达，且存在一定的相关性。
Keywords
结直肠腺癌； bcl-2蛋白； β-catenin，免疫组织化学Full Text
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colorectal cancer patients after curative surgery: a systematic
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colorectal cancer progression and its liver metastasis by
targeting BCL9 and BCL2[J]. Cancer Med,2021,10(10):3358-
3372.
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the proliferation and migration of lung adenocarcinoma by
targeting BCL2[J]. Thorac Cancer,2020,11(6):1396-1405.
[4]Zhao H, Ming T, Tang S, Ren S, Yang H, Liu M, Tao Q,
Xu H. Wnt signaling in colorectal cancer: pathogenic role and
therapeutic target. Mol Cancer. 2022 Jul 14;21(1):144.
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beta-catenin accumulation as a predictor of hematogenous
metastasis in human colorectal cancer[J]. Oncology,
2000,59(4): 302-309.
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达及其临床意义[J].中国当代医药,2022,29(09):70-73.
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The Bcl-2 Family: Ancient Origins, Conserved Structures,
and Divergent Mechanisms. Biomolecules. 2020 Jan
12;10(1):128.
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Magné N, Rodriguez-Lafrasse C, Ardail D. Preferential targeting
of cancer stem cells in the radiosensitizing effect of ABT-737 on
HNSCC. Oncotarget. 2016 Mar 29;7(13):16731-44.
[9]Hockenbery D, Nuñez G, Milliman C, Schreiber RD,
Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane
protein that blocks programmed cell death. Nature. 1990 Nov
22;348(6299):334-6.
[10]Yoshino T, Shiina H, Urakami S, Kikuno N, Yoneda
T, Shigeno K, Igawa M. Bcl-2 expression as a predictive
marker of hormone-refractory prostate cancer treated with
taxane-based chemotherapy. Clin Cancer Res. 2006 Oct
15;12(20 Pt 1):6116-24.
[11]Perini GF, Ribeiro GN, Pinto Neto JV, Campos LT,
Hamerschlak N. BCL-2 as therapeutic target for hematological
malignancies. J Hematol Oncol. 2018 May 11;11(1):65.
[12]Neiheisel A, Kaur M, Ma N, Havard P, Shenoy AK.
Wnt pathway modulators in cancer therapeutics: An update on
completed and ongoing clinical trials. Int J Cancer. 2022 Mar
1;150(5):727-740.
[13]邹慧娟,郑航,李明君,等. Wnt信号通路在结肠癌中
的表达及其作用机制[J]. 中国老年学杂志,2016,14（ 36） ;3
373-3 374.
[14]Li Z, Yan Z, Xu C, Dong Y, Xiong Y, Dai Y.
Acetylshikonin attenuates angiotensin II-induced proliferation
and motility of human brain smooth muscle cells by inhibiting
Wnt/β-catenin signaling. Hum Cell. 2018 Jul;31(3):242-250.
[15]Lee SC, Kim OH, Lee SK, Kim SJ. IWR-1 inhibits
epithelial-mesenchymal transition of colorectal cancer cells
through suppressing Wnt/β-catenin signaling as well as survivin
expression. Oncotarget. 2015 Sep 29;6(29):27146-59.
Copyright © 2023 徐 晨,于秀文
Publishing time:2023-03-29
This work is licensed under a Creative Commons Attribution 4.0 International License
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